二甲双胍对多囊卵巢综合征患者性激素水平、胰岛素抵抗及相关指标的影响被引量：42

Effect of Metformin on Sex Hormone,Insulin Resistance and Related Indexes in Women with Polycystic Ovarian Syndrome

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摘要目的:探讨二甲双胍对多囊卵巢综合征(PCOS)患者性激素水平、胰岛素抵抗及相关指标的影响。方法:79例PCOS患者作为PCOS组,另同期选择86例正常女性作为对照组。所有患者均给予二甲双胍片0.85 g,每日2次,共治疗6个月。观察PCOS组患者治疗前后的体质量、体质量指数(BMI)、腰围、臀围、腰臀比和糖化血红蛋白、血清睾酮(T)、硫酸脱氢表雄酮(DHEA-S)、雌二醇(E2)、黄体生成素(LH)、促卵泡刺激素(FSH)、泌乳素(PRL)、孕酮(PROG)、性激素结合球蛋白(SHBG)、空腹血糖(FPG)、空腹胰岛素(FINS)、LH/FSH、胰岛素抵抗指数(HOMA-IR)、游离雄激素指数(FAI)水平,并与对照组进行比较。结果:治疗过程中,有2例患者因妊娠停药,3例患者因发生胃肠道副反应停药,2例患者失访,最终共有72例患者完成治疗。治疗后,PCOS组患者体质量、BMI、腰围、臀围、糖化血红蛋白、FINS、HOMA-IR、T、LH、LH/FSH、PROG、FAI均显著低于同组治疗前,SHBG显著高于同组治疗前,且糖化血红蛋白、PROG低于对照组,腰围、FINS、HOMA-IR、LH/FSH、FAI高于对照组,差异均有统计学意义(P<0.05)。PCOS组患者腰臀比、FPG、DHEA-S、E2、FSH、PRL治疗前后比较差异无统计学意义(P>0.05)。结论:二甲双胍可有效改善PCOS患者的性激素水平和胰岛素抵抗状态。 OBJECTIVE： To investigate the effect of metformin on sex hormone level, insulin resistance and related indexes in women with polycystic ovarian syndrome （PCOS）. METHODS： 79 PCOS women were collected as PCOS group, other 86 healthy women as control group. All patients received 0.85 g Metformin tablet, twice a day, for totally 6 months. Boby mass, BMI, waist circumference, hip circumference,ratio of waist to hip, glyeated hemoglobin, T, DHEA-S, E2, LH, FSH, PRL, PROG, SHBG, FPG, FINS, LH/FSH, HOMA-IR and FAI before and after treatment in PCOS group were observed and compared with control group. RESULTS： During treatment, 2 patients made withdrawal because of pregnancy, 3 made withdrawal because of showing gastrointestinal side effects, 2 were lost to follow, totally 72 completed it. After treatment, body mass, BMI, waist circumference, hip circumference, glycated hemoglobin, FINS, HOMA-IR, T, LH, LH/FSH, PROG, FAI in PCOS group were significantly low- er than before, SHBG was significantly higher than before, glycated hemoglobin and PROG were lower than control group, while waist circumference, FINS, HOMA-IR, LH/FSH and FAI were higher than control group, the differences were statistically signifi- cant （P〈0.05）. There was no significant difference in ratio of waist to hip, FPG, DHEA-S, E2, FSH and PRL before and after treatment （P〉0.05）. CONCLUSIONS： Metformin can effectively improve the sex hormone levels and insulin resistance of patients with PCOS.

作者任春琼肖涌李毅任海霞

机构地区宜宾市疾病预防控制中心雅安市人民医院内分泌科雅安市人民医院妇产科宜宾市第一人民医院

出处《中国药房》 CAS 北大核心 2016年第27期3791-3794,共4页 China Pharmacy

关键词多囊卵巢综合征二甲双胍性激素胰岛素抵抗 Polycystic ovary syndrome Metformin Sex hormone Insulin resistance

分类号 R711.75 [医药卫生—妇产科学]

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