摘要
[目的]探讨奥美拉唑治疗小儿胃食管反流性哮喘疗效及对肺功能、炎性因子、免疫功能的影响。[方法]入组胃食管反流性哮喘患儿86例依据随机数字表法随机分为观察组43例与对照组43例。2组均采用常规处理,对照组采用必可酮气雾剂治疗,观察组在对照组基础上结合奥美拉唑治疗。2组疗程均为8周。[结果]2组患儿胃食管反流症状和哮喘症状评分治疗后明显减少(P<0.05);观察组患儿胃食管反流症状和哮喘症状评分治疗后低于对照组(P<0.05);2组FEV1、PEF治疗后明显增加(P<0.05);2组FEV1、PEF治疗后高于对照组(P<0.05);2组患儿IL-5治疗后明显降低(P<0.05),IL-10治疗后明显增加(P<0.05);观察组患儿IL-5治疗后低于对照组(P<0.05),IL-10高于对照组(P<0.05);2组患儿CD3+、CD4+、CD4+/CD8+治疗后明显增加(P<0.05),CD8+治疗后明显降低(P<0.05);观察组患儿CD3+、CD4+治疗后高于对照组(P<0.05),CD8+治疗后低于对照组(P<0.05);2组均未见严重药物不良反应。[结论]奥美拉唑治疗小儿胃食管反流性哮喘疗效显著,可明显改善患儿肺功能、微炎症状态、免疫功能,改善具有重要研究价值。
[Objective]To investigate the effect of omeprazole in the treatment of gastroesophageal reflux asthma in children and the effect on lung function,inflammatory factors and immune function.[Methods]86children with gastroesophageal reflux were randomly divided into observation group（43cases）and control group（43cases）.After the two groups were treated with conventional treatment,the control group was treated with Becotide Spray,while the observation group was treated with omeprazole on the basis of the control group.The course of treatment was 8weeks in two groups.[Results]Two groups of children with gastroesophageal reflux symptoms and asthma symptoms score after treatment was significantly reduced（P〈0.05）;observation group of children with gastroesophageal reflux symptoms and asthma symptoms score after treatment was lower than the control group（P〈0.05）;after treatment,two groups of FEV1 and PEF were significantly increased（P〈0.05）;the two groups of FEV1 and PEF after treatment were higher than those in the control group（P〈0.05）;after treatment,the two groups＇ IL-5were significantly decreased（P〈0.05）,IL-10 was significantly increased（P〈0.05）;IL-5of the observation group after treatment was lower than the control group（P〈0.05）,while IL-10 was higher than the control group（P〈0.05）;CD3＋,CD4＋,CD4＋/CD8＋after treatment of the two groups of children significantly increased（P〈0.05）,CD8＋after treatment significantly decreased（P〈0.05）;CD3＋,CD4＋after treatment of observation group was higher than the control group（P〈0.05）,CD8＋after treatment was lower than the control group（P〈0.05）;No serious adverse drug reactions were found in the two groups.[Conclusion]the curative effect of omeprazole in the treatment of children with gastroesophageal reflux asthma is significant.It can obviously improve the pulmonary function,micro inflammatory state,immune function,and it has important research value.
出处
《中国中西医结合消化杂志》
CAS
2016年第8期600-603,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
奥美拉唑
小儿胃食管反流性哮喘
疗效
肺功能
免疫功能
omeprazole
gastroesophageal reflux asthma in children
efficacy
pulmonary function
immune function
