摘要
目的：分析孕期服用抗甲状腺药物（ATDs）对新生儿甲状腺功能的影响。方法选取2012年1月至2014年1月出生5-7 d，且新生儿母亲妊娠期合并甲状腺功能亢进的106例新生儿作为研究对象。根据母亲妊娠期甲状腺功能状态以及开始服用甲状腺药物的时间进行分组，分析新生儿甲状腺功能的异常发生率及其影响因素。结果本研究106例中新生儿甲状腺功能异常发生率为50.00%，其中甲状腺功能低下占47.17%，高甲状腺激素血症占30.19%，低甲状腺素血症占15.09%，中枢性甲状腺功能减退占7.55%；妊娠期甲状腺功能亢进晚期母亲开始服用抗甲状腺药物治疗组的新生儿甲状腺功能异常发生率明显增加，组间比较差异有统计学意义（P 〈0.05）。结论母亲甲状腺功能亢进症晚期可增加新生儿甲状腺异常发生率，因此应做到早期诊断与治疗，对减少新生儿甲状腺功能异常的发生有重要意义。
Objective To analyze the effect of anti thyroid drugs（ATDs）during pregnancy on thyroid function of newborn. Methods One hundred and six cases of newborn who were borned from January 2012 to 2014 were selected. Their mothers had hyperthyroidism over pregnancy. They were divided into different groups according to maternal gestational thyroid function status and the time of the beginning of thyroid gland drugs. The neonatal thyroid functions and its influencing factors were analyzed. Results Among the 106 cases of newborn,the rate of the abnormal,hypothyroidism,high TSH hyperlipi-demia,hypothyroxinemia,central hypothyroidism was 50. 00% ,47. 17% ,30. 19% ,15. 09% ,7. 55% re-spectively. The abnormal rate of newborn whose mother taking ATDs in late hyperthyroidism over pregnancy was significantly higher（P 〈 0. 05）. Conclusions Suffering from late stage of maternal hyperthyroidism can significantly increase the incidence of neonatal thyroid abnormalities,so early diagnosis and treatment should be conducted to reduce the incidence of thyroid dysfunction in neonates.
出处
《中国实用医刊》
2016年第17期74-76,共3页
Chinese Journal of Practical Medicine
