摘要
目的:探讨基于双能量CT肺灌注成像的肺实质相对强化值在评估肺动脉栓塞短期预后中的临床应用价值。方法:45例经双能量CT肺灌注成像证实的肺动脉栓塞患者纳入本研究。根据短期临床预后结果分为预后不良组(n=24)和预后良好组(n=21)。利用双能量后处理软件lung PBV计算全肺的相对强化值。采用Mann-Whitney U检验比较两组相对强化值的差异,采用受试者工作特征曲线(ROC)分析该指标的最佳诊断阈值,并计算该阈值的诊断效能。结果:预后不良组的相对强化值(34.4%±7.0%)明显低于预后良好组(118.6%±13.1%),差异有统计学意义(Z=-3.6,P<0.05)。ROC曲线下面积为0.813,相对强化值的最佳诊断阈值为67%,该阈值诊断肺栓塞短期预后的敏感度为70.8%,特异度为81%。结论:基于双能量CT肺灌注成像的肺实质相对强化值能够有效预测肺动脉栓塞的短期预后,可作为肺动脉栓塞短期预后的评估参数。
Objective：To evaluate the value of the relative enhancement ratio （RER） of lung perfusion blood volume （PBV） in dual-energy computed tomography pulmonary angiography （CTPA） for assessment of the short-term prognosis of pulmonary embolism （PE）. Methods：45 patients with PE underwent dual-energy CTPA. The patients were divided into group A （n=24） and group B （n=21） based on the clinical outcome within 30 days. The RER of lung PBV was evaluated automatically on a workstation. The difference of RER between the two groups was compared using Mann Whitney U test. Receiver operator characteristic （ROC） analysis was performed to evaluate the cutoff value of the RER. Results： There was a statistical significance for the RER between the two groups （group A： 34.4 ± 7.0 % vs group B： 118. 6 ±13. 1%, P〈 0.05）. The ROC area was 0.81. The diagnostic sensitivity and specificity of RER were 70.8% and 81 %, respectively, with 67% as the cutoff value. Conclusions： Relative enhancement rate can serve as a new evaluation biomarker for indicating short-term adverse clinical outcome in patients with PE.
出处
《放射学实践》
北大核心
2016年第9期804-807,共4页
Radiologic Practice
关键词
肺灌注
肺栓塞
双能量CT
相对强化值
体层摄影术
X线计算机
Pulmonary perfusion
Pulmonary embolism
Dual energy CT
Relative enhancement rate
Tomography, X-ray computed
