摘要
目的:在睡眠脑电图引导下的Quisi快速检测法的建立,并探讨Quisi在老年失眠症诊断中的价值。方法:对64例老年失眠症患者和56名正常老年受试者同时做Quisi和睡眠脑电图(PSG)检测。并以日本SEEG-1518K为检测标准,与德国Quisi进行比较研究。同时做失匹性负波检测。结果:(1)在56名正常老年受试者中,除暂停、伪迹和第3、第4阶段4项睡眠参数Quisi和PSG两工具不能比较外,其他11项指标比较差异均无统计学意义(P>0.05)。(2)老年失眠症组与正常老年受试者Quisi比较,主要见:实际睡眠时间减少[分别为(350.1±29.5)分和(463.9±22.7)分,P<0.01],睡眠潜伏期长[分别为(34.6±18.9)分和(20.0±8.8)分,P<0.01],醒觉时间长[分别为(37.9±16.1)分和(17.2±6.6)分,P<0.01],睡眠效率低[分别为(87.5±8.1)分和(96.0±5.0)分,P<0.01],第一阶段睡眠百分比高[分别为(30.9±18.2)分和(9.2±1.7)分,P<0.01],第三、第四阶段睡眠百分比低[分别为(9.0±5.5)分和(17.1±4.8)分,P<0.01]。(2)与正常老人组相比,老年失眠症组MMN潜伏期延迟,波幅下降(P<0.01)。与此同时,P300也见同一趋势变化(P<0.05或0.01)。结论:(1)Quisi检测作用与PSG相似,在心理咨询、外出巡诊和家庭病床上有应用前途,运用Quisi技术评估老年失眠症患者的睡眠生理学异常,更为快速简便和客观科学。(2)MMN和P300两个指标在临床上作为睡眠脑电检测的一种补充手段。
Objective： To explore the application of Quisi under the guide of polysomnography and its diagnostic value in aged patients with into insomnia. Methods： Sleep EEG were recorded in 64 aged patients with insomnia and 56 normal aged people by German Quisi and Japanese SEEG-1518K instruments, and Sleep EEG from Quisi and SEEG-1518K was compared in the study. Meanwhile their mismatching negativity was tested. Results： （ 1 ） In normal aged group, no differences were found among 11 sleep variables from Quisi and SEEG-1518K instruments （P 〉 0.05）, other than pause, artifacts, S3, and S4, which could not be compared （ 2 ） Under the guide of PSG, sleep variables from in normal controls, showed that reduced actual slee 463.9 ± 22.7, P 〈 0.01 ） , prolonged sleep latency Quisi in aged patients with insomnia, compared with that time （ insomnia patients： 350.1 ± 29.5, normal controls insomnia patients： 34.6 ± 18.9, normal controls： 20.0 ± 8.8, P 〈 0.01 ） , increased awakening time （ insomnia patients： 37.9 ± 16.1, normal controls： 17.2 ± 6.6, P 〈 0.01 ） , decreased sleep efficiency （ insomnia patients： 87.5 ± 8.1, normal controls： 96.0 ± 5.0, P 〈 0.01 ） , increased （ insomnia patients： 30.9 ± 18.2, normal controls： 9.2 ± 1.7, P 〈 0.01 ） , reduced S3 （ insomnia patients 9.0 ± 5.5, normal controls： 17.1 ± 4.8, P 〈 0.01 ） , and higher artifacts percentage （ insomnia patients： 7.5 ± 2.1, normal controls： 2.8 ± 1.1, P 〈 0.01 ） . （ 3 ） Compared with the NC, the MMN in aged patients with insomnia had decreased amplitude and increased latency. Meanwhile, P300 also has the same tendency （P 〈 0.05 or 0.01 ） . Conclusion： （ 1 ） Compared to PSG, Quisi has the similar efficiency for evaluating insomnia and may be easily applicable to patients from psycho-consuting, out-diagnosing and family-ward. （ 2 ） MMN and P30o can be used as complementary means in clinic work.
出处
《现代电生理学杂志》
2016年第3期129-134,共6页
Journal of Modern Electrophysiology
基金
上海市科学技术委员会科技引导项目(编号:134119a2502)
关键词
QUISI
睡眠脑电图
老年失眠症
失匹性负波
Quisi
polysomnography
insomnia
electroneurophysiology
mismatching negativity
