摘要
目的观察康复新液(美洲大蠊提取物)联合泮托拉唑治疗高血压性脑出血并发上消化道出血的效果。方法选择91例高血压脑出血患者,随机分为对照组与治疗组,对照组使用西米替丁注射液,治疗组使用康复新液及抑酸、保护胃黏膜的泮托拉唑注射液。观察两组上消化道出血停止情况、血常规、肝肾功能的血红蛋白、白细胞、白蛋白、转氨酶、尿素氮等指标及预后情况。结果治疗组显效率(52.2%)明显高于对照组(27.3%)(P<0.05)。治疗组第3、7天,血红蛋白、白蛋白水平显著高于对照组,转氨酶、尿素氮水平显著低于对照组(P<0.05,P<0.01)。治疗1个月,对照组死亡率达25.0%(11/44),治疗组降至为17.0%(8/47),具有显著性差异(P<0.05)。结论康复新液联合泮托拉唑能有效预防高血压性脑出血患者上消化道出血的发生及减少上消化道出血时间,能有效减少并发症发生,改善预后。
AIM To observe the effect of Kangfuxin Liquid（ Periplaneta americana extract） combined with pantoprazole in the treatment of hypertensive cerebral hemorrhage concomitant with upper gastrointestinal hemorrhage. METHODS Selected ninety-one patients with hypertensive cerebral hemorrhage were randomly divided into control group（ Cimetidine Injection） and treatment group（ Kangfuxin Liquid combined with Pantoprazole Injection,the latter used for the acid suppression and the protection of gastric mucosa）. The clinical indices were observed,including the stop condition of upper gastrointestinal hemorrhage bleeding,blood routine examination,hemoglobin in hepatic and renal function,white blood cell,blood protein,transaminase,urea nitrogen,and the prognosis. RESULTS 52. 2% Marked effective rate in the treatment group was obviously higher than 27. 3% marked effective rate in the control group（ P〈0. 05）. In the treatment group,on the 3rdand 7thdays,the levels of hemoglobin and albumin were significantly higher than those in the control group,while the levels of transaminase and urea nitrogen were significantly lower than those in the control group（ P〈0. 05,P〈0. 01）. In the first month of treatment,the mortality of the control group reached 25. 0%（ 11 /44）,but that of the treatment group was reduced to 17. 0%（ 8 /47）,showing significant difference（ P〈0. 05）. CONCLUSION Kangfuxin Liquid combined with pantoprazole can efficiently prevent the upper gastrointestinal hemorrhage of patients with hypertensive cerebral hemorrhage,reduce the bleeding time,decrease the complications,and improve the prognosis.
出处
《中成药》
CAS
CSCD
北大核心
2016年第9期1914-1917,共4页
Chinese Traditional Patent Medicine
基金
贵州省科技基金(黔科合SY字[2015]3041)
关键词
高血压性脑出血
上消化道出血
康复新液
泮托拉唑
西米替丁
hypertensive cerebral hemorrhage
upper gastrointestinal bleeding
Kangfuxin Liquid
pantoprazole
cimetidine
