摘要
白细胞介素-6（IL-6）是一种多功能的细胞因子，参与细胞多种生物功能。IL-6的跨膜信号转导主要分为两种，即经典通路和反式信号通路，通过IL-6／酪氨酸激酶-1（JAK-1）／信号转导和转录激活因子-3（STAT-3）途径发挥其生物学作用。研究发现，IL-6能够抑制甲状腺细胞的分泌功能及摄碘功能。其次，在临床中发现，IL-6水平升高不仅与Graves病、桥本甲状腺炎显著相关，而且IL-6基因多态性与Graves病及桥本甲状腺炎的发病关系密切。另外，研究发现，IL-6在甲状腺癌的发病机制中亦扮演重要的角色。
Interleukin（IL）-6 is a multifunctional cytokine involved in multiple biological functions of cells. Transmembrane signaling of IL-6 is divided into two types, the classical pathway and the trans-signaling pathway, and it plays biological effect via IL-6/Janus kinase-1 （JAK1）/signal transducers and activators of transcription-3 （ STAT3 ） signal pathway. The study found that IL-6 could inhibit the secretion of thyroid cells and iodine uptake function. Secondly, clinical study found that the level of IL-6 was increased significantly in Graves＇ disease and Hashimoto＇s thyroiditis, and IL-6 geue poiymorphism was closely related with Graves＇ disease and Hashimoto＇s thyroiditis. In addition, IL4 also plays an important role in the patho- genesis of thyroid eareinoma.
出处
《国际内分泌代谢杂志》
2016年第5期352-354,共3页
International Journal of Endocrinology and Metabolism
