摘要
目的探讨先期化疗联合肿瘤细胞减灭术后腹腔热灌注化疗治疗晚期卵巢癌的临床疗效。方法将58例卵巢癌患者随机分为对照组和实验组。对照组采用常规肿瘤细胞减灭术联合术后腹腔热灌注化疗(TC/TP方案),实验组在对照组基础上于术前行新型辅助化疗,对比分析2组患者临床治疗效果。结果实验组手术时间、术中出血量、腹水量以及术后感染率明显优于对照组,差异有统计学意义(P<0.05),但2组患者在住院时间上差异无统计学意义(P>0.05)。实验组患者治疗疗程结束后外周血免疫相关指标因子CD3^+CD4^+、CD3^+CD56^+以及CD3^+CD4^+/CD3^+CD8^+与对照组相比,上升趋势更明显,差异具有统计学意义(P<0.05)。实验组治疗疗程结束后总有效率为72.4%,显著高于对照组(41.4%),具有统计学意义(P<0.05);实验组与对照组在癌肿的复发率、死亡率以及1年生存率上差异不具统计学意义(P>0.05)。结论先期化疗联合肿瘤细胞减灭术后腹腔热灌注化疗对晚期卵巢癌的近期疗效显著,可有效改善患者免疫抑制现象。
Objective To discuss the clinical effecacy of neoadjuvant chemotherapy combined with intraperitoneal hy- perthermic chemoperfusion for advanced ovarian cancer after cytoreductive surgery. Methods 58 patients with ovarian cancer were randomly divided into the control group and the experimental group. The control group used conventional cytoreductive sur- gery combined with intraperitoneal hyperthermic chemoperfusion （TC/TP regimen） , and the experimental group was treated with neoadjuvant chemotherapy on the basis of the control group. The clinical therapeutic effects between the 2 groups were compared. Results The operation time, bleeding volume, ascites volume and postoperative infection rate of the experimental group was sig- nificantly better than those of the control group （ P 〈 0.05 ） , but there was no significant difference between the 2 groups in hospi- talization time （P 〉 0.05 ）. In the experimental group, after the end of the treatment, the peripheral blood immune related factor CD3 CD4 ＋ , CD3 CD56 ＋ and CD3 ＋ CD8 ＋/CD3 ＋ CD4 ＋ were significantly higher than those of the control group （ P 〈 0.05 ）. In the experimental group after treatment, the total efficiency （72.4%）was significantly higher than that of the control group （41.4%） （P 〈 0.05 ）. The recurrence and mortality rates, and 1-year survival rates of the experimental group and the control group had no statistical difference（ P 〉 0.05 ）. Conclusion Neoadjuvant chemotherapy combined with intraperitoneal hyperther- mic chemoperfusion in the treatment of advanced ovarian cancer after cytoreductive surgery have significant short-term efficacy,it can effectively improve the immune suppression.
出处
《实用癌症杂志》
2016年第9期1495-1497,共3页
The Practical Journal of Cancer
关键词
卵巢癌
先期化疗
肿瘤细胞减灭术
腹腔热灌注化疗
Neoadjuvant chemotherapy
Advanced ovarian cancer
Intraperitoneal hyperthermic chemoperfusion
Cytore-ductive surgery
