摘要
目的探讨在皮肤恶性黑色素瘤手术治疗中联合免疫治疗的临床疗效。方法回顾性分析收治的皮肤恶性黑色素瘤患者52例,根据治疗方式不同分为治疗组33例和对照组19例。两组患者均行根治手术治疗;对照组在根治术后直接进行移植皮修复。治疗组在根治术后应用免疫疗法。比较两组患者整个治疗过程所需时间和出血量;比较治疗后第1年、第2年和第3年患者生存率;检测两组血清基质金属蛋白酶-2(MMP-2)和基质金属蛋白酶-9(MMP-9)水平。结果治疗组患者整个治疗过程平均所需时间和出血量分别为(2.25±0.43)h和(595.78±149.72)m L,与对照组(2.34±0.51)h和(604.27±155.33)m L比较差异无统计学意义(P<0.05,P<0.01);治疗后,治疗组患者第2和第3年的生存率明显高于对照组(P<0.05);治疗组治疗后MMP-2和MMP-9水平均明显低于对照组,差异有统计学意义(P<0.01)。结论在皮肤恶性黑色素瘤手术治疗中采取免疫疗法可提高治疗效果、提高术后生存率和降低血清MMP-2和MMP-9含量,值得临床应用。
Objective To study the clinical value of immunotherapy in operation treatment for cutaneous malignant mel- anoma. Methods 52 cases of cutaneous malignant melanoma were randomly divided into the treatment group and the control group by different operation treatment. The control group was treated by free tissue flap transplantation after tumor resection. The treatment group was treated by immunotherapy during operation treatment, and then free tissue flap transplaatation. Time and a- mount of bleeding of whole treatment course were compared between the 2 groups. 1-,2- and 3-year survival rates were compared Serum levels of MMP-2 and MMP-9 were detected of the 2 groups. Results Time and amount of bleeding of whole treatment course in the treatment group were （2.25 ± 0.43 ） h and （595.78 ± 149.72） mL, which were lower than （2.34 ±0.51 ） h and （604.27 ± 155.33 ） mL in the control group （ P 〉 0.05 ）. After treatment,2- and 3-year survival rates of the treatment group were obviously higher than those of the control group （P 〈 0. 05 ）. Serum levels of MMP-2 and MMP-9 in the treatment group were re- markably lower than those of the control group （P 〈 0.01 ）. Conclusion In operation treatment of cutaneous malignant melano- ma,immunotherapy could increase efficacy, improve survival rate, and decrease serum levels of MMP-2 and MMP-9,it is worthy of clinical application.
出处
《实用癌症杂志》
2016年第9期1553-1555,共3页
The Practical Journal of Cancer
