摘要
目的 研究麝香保心丸联合西药治疗老年急性心肌梗死（AMI）的临床疗效。方法 选择2014年1月-2015年6月于河北北方学院附属第一医院老年内科接受治疗的老年急性心肌梗死（AMI）患者88例,按随机数字表法1：1分为联合组（44例）与对照组（44例）。对照组行急诊冠状动脉介入治疗联合阿司匹林、氯吡格雷治疗;联合组在对照组治疗基础上联合麝香保心丸治疗。观察两组治疗前及治疗2个月后三酰甘油（TG）、胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）,左室射血分数（LVEF）、左室舒张末期容积（LVEDV）、左室收缩末期容积（LVESV）;高敏C反应蛋白（hs-CRP）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）的变化,治疗前及治疗24 h后血浆乳酸脱氢酶（LDH）、超氧化物歧化酶（SOD）、心肌钙蛋白T（c Tn T）、肌酸激酶同工酶（CK-MB）的变化,并记录不良反应。结果 治疗后,联合组TG、TC、LDL-C、HDL-C水平均低于对照组（P均〈0.05）,LVEF水平高于对照组（P〈0.05）,LVEDV、LVESV水平均低于对照组（P均〈0.05）。联合组hs-CRP、IL-8、TNF-α水平均低于对照组（P均〈0.05）。治疗24 h后联合组LDH、CK-MB、c Tn T水平均低于对照组（P均〈0.05）,SOD水平高于对照组（P〈0.05）。联合组总有效率（93.18%）高于对照组（75.00%）,有统计学差异（P〈0.05）。两组治疗期间均未发生显著不良反应。结论 麝香救心丸联合西药治疗老年AMI疗效显著,无显著不良反应,值得应用于临床。
Objective To explore the effect of heart musk of pill combined western medicine for acute myocardial infarction（AMI） in elderly patients. Methods 88 AMI patients in the first hospital affiliated to Hebei institute of north from Jan 2014 to Jun 2015 were randomly divided into joint group（n=44） and control group（n=44）. Control group underwent emergency coronary interventional therapy with aspirin and clopidogrel; joint group used heart musk of pill on the basis of treatment for control group. Triglyceride（TG）, cholesterol（TC）, low density lipoprotein（LDL-C）, high density lipoprotein（HDL-C）, left ventricular ejection fraction（LVEF）, left ventricular end-diastolic volume（LVEDV）, Left ventricular end-systolic volume（LVESV）; high-sensitivity C-reactive protein（hs-CRP）, interleukin-8（IL-8）, tumor necrosis factor-α（TNF-α） before and 2 months after treatment were measured. Plasma lactate dehydrogenase（LDH）, superoxide dismutase（SOD）, cardiac troponin T（c Tn T）, creatine kinase（CK-MB） before and 24 hours after treatment were measured. Adverse drug events were recorded. ResultsAfter treatment, TG, TC, LDL-C, HDL-C of joint group were lower than control group（P〈0.05）; LVEF was higher than control group（P〈0.05）; LVEDV and LVESV are lower than control group（P〈0.05）. Hs-CRP, IL-8, TNF-α of joint group were lower than control group（P〈0.05）. LDH, CK-MB and c Tn T of joint group were lower than control group（P〈0.05）; SOD of joint group was higher than control group 24 h after treatment（P〈0.05）. Total effective rate（93.18%） of joint group was higher than control group（75.00%）, with statistical difference（P〈0.05）. There was no adverse event during treatment. Conclusion Heart musk of pill in combination with western medicine is effective in AMI treatment of elderly patients with no adverse event, which is worth for clinical application.
出处
《中国循证心血管医学杂志》
2016年第9期1096-1099,共4页
Chinese Journal of Evidence-Based Cardiovascular Medicine
