摘要
目的:观察护肾通淋汤对肾结石体外冲击波碎石(ESWL)术后肾损伤的保护作用及对血清超氧化物歧化酶(SOD)和丙二醛(MDA)水平的影响。方法:128例肾结石患者随机分为对照组(63例)和观察组(65例)。两组均采用ESWL治疗,术后给予抗感染等对症处理,对照组口服排石颗粒,20 g/次,3次/d,连续服用14 d;观察组口服护肾通淋汤,1剂/d,连续服用14 d。记录腰痛减轻时间和肉眼血尿消失时间;于ESWL术后当天,7 d,14 d采取B超检测排石情况;于术后12 h,7 d,14 d检测SOD,MDA,β_2微球蛋白(β_2-MG),尿N-乙酰-β-氨基葡萄糖苷酶(NAG)和半胱氨酸蛋白酶抑制剂C(Cys C)水平。结果:观察组有效率为93.85%,高于对照组的82.54%(P<0.05);观察组腰痛减轻时间和肉眼血尿消失时间均短于对照组(P<0.01);ESWL治疗后7,14 d,观察组SOD水平显著高于对照组(P<0.01),MDA水平低于对照组(P<0.01);观察组NAG,β_2-MG和Cys C水平均低于同期对照组(P<0.01)。结论:护肾通淋汤用于肾结石ESWL术后患者,能缩短病程,提高临床疗效,减少并发症,并能抗氧化,减轻肾实质损伤,促进ESWL术后患者的康复。
Objective： To observe the protective effect of Hushen Tonglin decoction on kidney injury and its effects on levels of superoxide dismutase in blood serum（ SOD） and malonaldehyde（ MDA） in patients with kidney calculi after extracorporeal shock-wave lithotripsy（ ESWL）. Method： One hundred and twenty-eight patients with kidney calculi were randomly divided into control group（ 63 cases） and observation group（ 65cases）. Patients of both groups received ESWL treatment,and symptomatic treatment such as anti-infection was given after surgery. Patients in control group received Paishi capsules for 14 days,20 g / time,3 times / day.Patients in observation group took Hushen Tonglin decoction for 14 days,1 dose / day. Time of lumbago relief and disappearance time of gross hematuria were recorded. At the 1th,7th and 14 th day after operation,the removed calculi were detected by B-ultrasound. At the 12th hour,7th and 14th day after operation,levels of SOD,MDA,β2-microglobulin（ β2-MG）,urinary N-acetyl-β-glucosaminidase（ NAG） and cysteine protease inhibitors（ Cys C） were detected. Result： The effective rate was 93. 85% in observation group,higher than 82. 54% in control group（ P 〈0. 05）. The time of lumbago relief and disappearance time of gross hematuria in observation group were shorter than those in control group（ P 〈 0. 01）. At the 7th and 14thday after operation,level of SOD in observation group was higher than that in control group（ P 〈 0. 01）,and the levels of MDA,NAG,β2-MG and Cys C were lower than those in control group（ P 〈 0. 01）. Conclusion： Hushen Tonglin decoction can shorten the disease course,improve clinical efficacy,relieve complications with antioxidant effects,reduce renal parenchyma injury and promote the recovery of patients after ESWL in patients with kidney calculi.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第19期140-143,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
海南省自然科学基金项目(308978)
关键词
肾结石
体外冲击波碎石
护肾通淋汤
肾损伤
超氧化物歧化酶
丙二醛
kidney calculi
extracorporeal shock-wave lithotripsy
Hushen Tonglin decoction
kidney injury
superoxide dismutase
malonaldehyde
