摘要
目的探讨甲硝唑联合克林霉素治疗细菌性阴道炎患者的临床疗效及其安全性。方法选取2014年5月至2015年4月于我院妇科就诊的130例细菌性阴道炎患者,按照治疗方式的不同分为对照组和治疗组,每组各65例,其中对照组给予甲硝唑治疗,1次400mg,1日2次,治疗组在对照组的基础上加用克林霉素软膏,两组患者均持续治疗1周。对比分析两组患者的临床疗效,不良反应发生率和复发率。结果两组患者接受相应的治疗后,治疗组总有效率为96.9%,明显高于对照组的61.5%,差异有统计学意义(P<0.05)。治疗组患者的复发率明显低于对照组,且治疗组患者消化道反应、神经系统反应、肝功能损害和肾功能损害等不良反应的发生例数没有明显增加(P>0.05)。结论甲硝唑联合克林霉素治疗细菌性阴道炎,临床疗效显著,复发率低,安全性好,在临床上值得推广应用。
OBJECTIVE To explore the clinical effect and safety of metronidazole conbined with clindamyein in the treatment of bacterial vaginitis. METHODS 130 cases of patients with bacterial vaginitis treated in our hospital from May 2014 to April 2015 were selected and divided into control group and treatment group according to the dif- ferent treatment methods, each group contains 65 cases. The control group was treated with metronidazole ,400rag per times ,2 times per day,the treatment group were additional received clindamycin ointment, two groups of patients were treated for 1 week. The clinical efficacy, adverse reaction rate and recurrence rate of the two groups were compared and analyzed. RESULTS After the treatment,the total effective rate of the treatment group was 96.9% ,which was significantly higher than that of the control group, the difference was statistically significant （ P 〈 0.05 ）. The recur- rence rate of the observation group was significantly lower than that of the control group and the cases of adverse reac- tions including gastrointestinal reaction, nervous system reactions, liver function damage and renal function damage does not increase significantly in observation group （ P 〉 0. 05 ）. CONCLUSION The clinical effect of metron- idazole combined with clindamycin in the treatment of bacterial vaginosis is significant and the recurrence rate is low, it is worthy of popularization and application in clinic.
出处
《海峡药学》
2016年第9期81-83,共3页
Strait Pharmaceutical Journal
关键词
甲硝唑
克林霉素
细菌性阴道炎
临床疗效
Metronidazole
Clindamycin
Bacterial Vaginosis
Clinical effect
