摘要
目的观察柴胡疏肝汤加浙贝母治疗难治性癫痫的临床疗效。方法将120例难治性癫痫患者随机分为治疗组和对照组各60例。对照组根据不同发作类型选服常规剂量的抗癫痫西药。治疗组在对照组基础上予柴胡疏肝汤加浙贝母,每日1剂,早晚各1次。两组疗程均为16周,随访24周,于治疗前8周、治疗8周后、治疗16周后、随访期(疗程结束后每8周随访1次,共随访3次)比较两组患者癫痫发作频率和脑电图异常率,并于治疗16周后评价临床疗效。结果治疗组临床总有效率为88.33%优于对照组的76.67%(P<0.05)。治疗后两组患者治疗与随访不同时间点平均癫痫发作的频次及脑电图异常率均较治疗前有下降(P<0.05);且治疗组治疗与随访不同时间点改善均优于对照组(P<0.05)。结论柴胡疏肝汤加浙贝母治疗难治性癫痫效果显著,可降低癫痫发作频率,改善脑电图情况。
Objective To observe clinical effects of Chaihu Shugan Decoction（柴胡疏肝汤） combined with Zhebeimu（ Fritillaria Thunbergii Miq.） treating intractable epilepsy. Methods One hundred and twenty patients with intractable epilepsy were randomly divided into the treatment group and the control group with 60 in each group.The control group chose anti-epileptic western medicine of regular dosage according to different attack types. On the basis of the control group,the treatment group took Chaihu Shugan Decoction combined with Zhebeimu（ Fritillaria Thunbergii Miq.）,1 dose a day,once in the morning and once in the evening. The treatment last for 16 weeks. The follow-up last for 24 weeks,including 8 weeks before treatment,8 weeks after treatment,16 weeks after treatment and follow-up period（ once in every 8 weeks after the course of treatment,3 times in total）. The researchers compared the seizure frequency of epileptic and the abnormal rate of EEG in the two groups and evaluated the clinical effects.Results The clinical total effective rate was 88. 33 % in the treatment group,better than that 76. 67 % in the control group（ P〈0. 05）. Compared with those before treatment,the average seizure frequency of epileptic and the abnormal rate of EEG decreased at different time points in treatment and follow-up visit after treatment in the two groups（ P〈0. 05）; And the improvement at different time points in treatment and follow-up visit in the treatment group was better than that in the control group（ P〈0. 05）. Conclusion Chaihu Shugan Decoction combined with Zhebeimu（Fritillaria Thunbergii Miq.） treating intractable epilepsy had remarkable effects,and can reduce seizure frequency of epileptic and improve EEG.
作者
何乾超
陈炜
刘泰
胡跃强
夏猛
吴林
黄德庆
梁妮
HE Qianchao CHEN Wei LIU Tai HU Yueqiang XIA Meng WU Lin HUANG Deqing LIANG Ni(The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, 530023 Guangxi Scientific Research Center of Traditional Chinese Medicine)
出处
《中医杂志》
CSCD
北大核心
2016年第19期1662-1665,共4页
Journal of Traditional Chinese Medicine
基金
广西壮族自治区卫生厅中医药科技专项(GZPT13-10)
广西壮族自治区临床重点专科建设项目(桂卫医发2015[5]号)
关键词
癫痫
柴胡疏肝汤
浙贝母
epilepsy
Chaihu Shugan Decoction（柴胡疏肝汤）
Zhebeimu（Fritillaria thunbergii Miq.）
