炔雌醇环丙孕酮联合二甲双胍对多囊卵巢综合征患者内分泌及糖脂代谢的影响被引量：22

Effects of cyproterone acetate and ethinylestradiol combined metformin on the endocrinological function and glucose and lipid metabolism in polycystic ovary syndrome patients

下载PDF

导出

摘要目的分析炔雌醇环丙孕酮联合二甲双胍对多囊卵巢综合征内分泌及糖脂代谢的影响。方法选择在本院接受治疗的多囊卵巢综合征患者为研究对象，采用随机数字表法分为观察组和对照组，观察组接受炔雌醇环丙孕酮联合二甲双胍治疗，对照组接受炔雌醇环丙孕酮治疗。比较2组患者治疗后内分泌激素水平、血糖血脂水平及身体一般指标差异。结果观察组接受炔雌醇环丙孕酮联合二甲双胍治疗后，其月经恢复率、血清促卵泡激素（FSH）、黄体生成素（LH）、睾酮（T）、胰岛素（INS）、空腹血糖（FPG）、胰岛素抵抗（HOMA—IR）等内分泌水平，总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL—C）、高密度脂蛋白胆固醇（HDL—C）、载脂蛋白A（ApoA）、载脂蛋白B（ApoB）等血脂水平，体质指数（BMI）、腰臀比（WHR）值、多毛评分及痤疮评分值等身体状况的改善均优于对照组患者（P〈0．05）。结论炔雌醇环丙孕酮联合二甲双胍用于多囊卵巢综合征患者的治疗，可以有效优化患者的激素水平，降低高脂血症，对疾病康复具有积极意义。 Objective To evaluate the effects of cyproterone acetate and ethinylestradiol combined metformin on the endoerinological function and glucose and lipid metabolism in polycystic ovary syndrome （PCOS） patients. Methods P- COS patients who were admitted into our hospital were included in the current study and randomly divided into a control group and an observation group. The control group was treated with cyproterone acetate and ethinylestradiola alone, while the observation group was administrated with a combination of cyproterone acetate and ethinylestradiola and mefformin. Both groups were compared for the levels of hormone, blood glucose and lipid and physical condition after treatment. Re- stilts After the combined therapy, the observation group showed improved changes than the control in menstruation re- covery rate, follicle - stimulating hormone （ FSH）, luteotropic hormone （ LH）, testosterone （ T）, insulin （ INS）, fasting plasma glucose （FPG）, homeostasis model assessment- insulin resistance （HOMA- IR） as well as total cholesterol （ TC ）, triglyceride （ TG）, low - density lipoprotein - cholesterol （ LDL - c ）, high - density lipoprotein - cholesterol （ HDL -c）, lipoprotein A （ ApoA）, lipoprotein B （ApoB） and body mass index （ BMI）, waist - to - hip （WHR） rati- o, birsutism score, and ache score （P 〈 0.05 ）. Conclusions Treatment of PCOS patients with cyproterone acetate and ethinylestradiol combined metformin can effectively improve endocrinologieal function and glucose and lipid metabolism, which is beneficial for recovery.

作者赵松青方成霞刘正华陆卫平

机构地区南京医科大学附属淮安第一医院内分泌科

出处《徐州医学院学报》 CAS 2016年第9期578-581,共4页 Acta Academiae Medicinae Xuzhou

关键词多囊卵巢综合征炔雌醇环丙孕酮二甲双胍糖脂代谢内分泌 polyeystic ovary syndrome cyproterone acetate and ethinylestradiol metformin glucose - lipid metab- olism endocrine

分类号 R588.6 [医药卫生—内分泌]

引文网络
相关文献

参考文献12

1刘琼.五积散对多囊卵巢综合征痰湿型患者糖脂代谢及生殖激素的影响[J].中药材,2014,37(8):1502-1504. 被引量：20
2Carioglu A, Kaygusuz I, Karakurt F, et al. The platelet activating factor acetyl hydrolase, oxidized low - density lipoprotein, paraox- onase 1 and arylesterase levels in treated and untreated patients with polycystic ovary syndrome [ J]. Arch Gyneeol Obstet, 2014, 290(5) :929 -935.
3武红琴,阮祥燕,卢永军,田玄玄,张颖,刘玉兰,甄洁,Diethelm Wallwiener,Alfred O.Mueck.综合管理下达英-35与达英-35联合二甲双胍治疗多囊卵巢综合征的疗效研究[J].首都医科大学学报,2014,35(4):407-413. 被引量：55
4Victor VM, Rovira - Lopis S, Bafiuls C, et al. Metformin modu- lates human leukocyte/endothelial cell interactions and proinflam- matory cytokines in polycystic ovary syndrome patients [ J]. Ather- osclerosis, 2015,242( 1 ) :167 - 173.
5陈志敏,史惠蓉,任芳,曹媛.达英-35联合二甲双胍治疗伴胰岛素抵抗型多囊卵巢综合征疗效观察[J].中国妇幼保健,2012,27(6):934-936. 被引量：53
6A1 - Biate MA. Effect of metformin on early pregnancy loss in women with polyeystic ovary syndrome [ J]. Taiwan J Obstet Gyne- col, 2015,54 ( 3 ) :266 - 269.
7赵丽华.替米沙坦与二甲双胍联合治疗对高血压合并非酒精性脂肪性肝病患者血压和糖脂代谢的影响[J].中华高血压杂志,2012,20(3):282-284. 被引量：7
8鲁晓燕,刘曼华,郑艳莉,陶潜.达英-35联合二甲双胍治疗多囊卵巢综合征患者内分泌代谢紊乱疗效观察[J].苏州大学学报（医学版）,2010,30(3):641-643. 被引量：21
9Ghaneei A, Jowkar A, Hasani Ghavam MR, et al. Cabergoline plus metformin therapy effects on menstrual irregularity and andro- gen system inpolycystic ovary syndrome women with hyperpro- lactinemia [J]. lran J Reprod Med, 2015,13(2) :93 -100.
10Jensterle M, Kravos NA, Pfeifer M, et al. A 12 -week treatment with the long - acting glucagon - like peptide 1 receptor agonist liraglutide leads to significant weight loss in a subset of obese women with newly diagnosed polyeystic ovary syndrome [ J ]. Hor- mones ( Athens), 2015, 14 ( 1 ) :81 -90.

二级参考文献76

1李昕,林金芳.肥胖型多囊卵巢综合征患者临床及内分泌代谢特征的研究[J].中华医学杂志,2005,85(46):3266-3271. 被引量：139
2胡敏,侯丽辉,吴效科.瘦素与多囊卵巢综合征的研究进展[J].中国妇幼健康研究,2006,17(2):125-128. 被引量：9
3国家中医药管理局.中华人民共和国医药行业标准.中医病症诊断疗效标准[M].南京:南京中医药大学出版社,1994.201-203.
4Coviello AD, Legro RS, Dunaif A. Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance [ J].J Clin Endocrinol Metab, 2006,91 (2) :492 - 497.
5Sir-Petermann T,Maliqueo M,Codner E, et al. Early metabolic derangements in daughters of women with polycystic ovary syndrome [ J ]. Clin Endocrinol Metab, 2007,92 ( 12 ) : 4637 - 4642.
6Cagnacci A, Paoletti AM. Glucose metabolism and insulin resistance in women with polycystic ovary syndrome during therapy with oral contraceptives containing cyproterone acetate or desogestrel [ J 1. J Clin Endocrinol Metab, 2003,88 (8) :3621 - 3625.
7Loverro G, Lorusso F, De Pergola G, et al. Clinical and endoctrinological effects of months of metformin treatment in young hyperin-sulinemic patients affected by polycystic ovary syndrome [ J ]. Gynecol Endocrinol, 2002, 16 ( 3 ) : 217 - 224.
8Ng EH, Wat NM, Ho PC. Effects of metformin on ovulation rates, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: a randomized, doubleblinded placebo-controlled trial [ J ]. Hum Reprod, 2001,16 (8) : 1625 - 1631.
9Evanthia Diamanti-Kandarakis E,Christakou C D,Kandaraki E.Metformin:an old medication of new fashion:evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome.Ettr J Endocrinol,2010,162(2):193-212.
10The Rotterdam ESHRE//ASRM-Sponsored PCOS Workshop Group.Revised 2003 consensus on diagnostic criteria and long- term health risks related to Polycystic ovary syndrome.Fertil Steril,2004,81 (1): 19-25.