摘要
目的探讨小剂量硝苯地平(nifedipine,N)、阿替洛尔(atenolol,A)、氢氯噻嗪(hydrochlorothiazide,H)个体化方案治疗原发性高血压的临床疗效。方法对144例原发性高血压患者均给予高血压防治知识的宣传和健康生活方式的指导,并根据个体情况,指导合理膳食营养,戒烟、戒酒,适量运动,避免体质量超重。采用NAH治疗方案治疗,同时根据血压控制情况,计算机自动制定复诊日期。观察144例患者的依从性和治疗1、2、3周后临床疗效及不同高血压分级的血压控制率。结果 144例患者中,依从性好的患者132例(91.85%)。治疗2、3周后总有效率均明显高于治疗1周后(均P<0.01),治疗3周后总有效率明显高于治疗2周后(均P<0.05)。Ⅰ期高血压患者血压控制率与Ⅱ期、Ⅲ期高血压比较差异无统计学意义(P>0.05)。结论 NAH方案治疗原发性高血压有较好的疗效,能够提高患者药物治疗的依从性,值得临床应用。
Objective To explore the clinical effect of individualized treatment with low-dose nifedipine-atenolol-hydrochlorothiazide（NAH）on primary hypertension.Methods A total of 144 patients with primary hypertension were given the propaganda of hypertension prevention and treatment knowledge and the guidance on healthy lifestyles,including rational diet,smoking cessation,drinking cessation,appropriate exercise and avoidance of overweight.Furthermore,NAH treatment scheme was used in patients,and the date of subsequent visit was automatically managed by computer according to the blood pressure control.The compliance was observed,and the clinical efficacy and control rates of different grades of hypertension were measured after treatment for 1,2and 3weeks.Results Among the 144 patients,132（91.85%）had good compliance.The total effective rate after treatment for 2or 3weeks was higher than that after treatment for 1week,and that after treatment for 3weeks was higher than that after treatment for 2weeks（P〈0.05 or P〈0.01）.The blood pressure control rate in patients with gradeⅠ hypertension was not different from that in patients with grade Ⅱ or Ⅲ hypertension（P〉0.05）.Conclusion NAH scheme is effective for hypertension and improves medicine compliance in hypertension patients.Therefore,it is worthy of clinical application.
出处
《实用临床医学（江西）》
CAS
2016年第8期1-3,共3页
Practical Clinical Medicine
基金
国家科技惠民项目(2013GS360101)
