摘要
目的探讨同步放化疗联合手术治疗中低位进展期直肠癌的近远期疗效。方法选取2013年12月至2015年12月新疆医科大学第五附属医院收治的50例中低位进展期直肠癌患者,按照就诊时间顺序分为对照组和观察组,每组25例。对照组仅给予全直肠系膜切除术治疗,观察组在此基础上加用同步放化疗治疗,比较两组患者住院时间、手术时间、治疗前后肿瘤标志物水平、切缘无癌细胞切除率、保肛率、随访1年的局部复发率和转移率。结果观察组患者切缘无癌细胞切除率和保肛率明显升高,与对照组比较,差异有统计学意义(P<0.05)。两组患者治疗后较治疗前比较,CEA、CA19-9、CA242水平均降低,观察组上述指标降低更加显著,与对照组比较,差异有统计学意义(P<0.05)。观察组患者随访1年局部复发率和远处转移率均较低,与对照组比较,差异有统计学意义(P<0.05)。结论同步放化疗联合手术治疗中低位进展期直肠癌的近期疗效显著,远期复发率和转移率较低,具有一定的临床意义。
Objective To explore and analyze short and long term efficacy of radiochemotherapy combined with surgery for advanced lower colorectal. Methods A total of 50 sequential patients with advanced lower colorectal cancer treated in The Fifth Affiliated Hospital of Xinjiang Medical University from December 2013 to December 2015 were included. Patients were divided into surgical group and combined therapy group,with 25 patients in each group. Patients in the observational group received concurrent radiochemotherapy combined with the surgery of total mesorectum excision while patients in the control group only received surgery. Length of hospital stay,operative time,levels of tumor markers before and after treatment,resection rate of non-cancerous cells near the cut edge,anal conservation rate and rate of local recurrence and metastasis after 1 year＇s follow-up were compared between two groups. Results Compared with control group,resection rate of non-cancerous cells near the cut edge and anal conservation rate increased significantly in the combined therapy group（ P〈0. 05）. After treatment,levels of CEA,CA19-9 and CA242 are lower in both groups. The above index reduced even more significant in the combined therapy group compared with control group（ P〈0. 05）. Local recurrence rate and distant metastasis rate after 1year＇s follow-up were lower in combined therapy group than control group（ P〈0. 05）. Conclusion Radiochemotherapy combined with surgery in patients with advanced lower colorectal cancer shows a remarkable short-term effect,with low rate of metastasis and recurrence.
出处
《中国肿瘤临床与康复》
2016年第9期1085-1087,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
结直肠肿瘤
同步放化疗
药物疗法
治疗结果
Colorectal neoplasms
Concurrent chemoradiotherapy
Drug therapy
Treatment outcome
