摘要
目的研究高血压早期肾损害患者采用依那普利联合乐卡地平治疗的临床效果。方法纳入我院2013年6月至2015年6月期间收治的84例高血压肾损害患者,将所有患者按随机数字表法分为两组各42例。其中42例患者单纯给予依那普利治疗作为对照组,另42例患者在上述基础上联合乐卡地平治疗作为观察组。观察两组患者治疗效果、肾功能情况及不良反应。结果观察组、对照组治疗总有效率分别为95.24%、78.57%,观察组高于对照组,P<0.05。治疗前两组患者SBP、DBP无差异,P>0.05;治疗后观察组SBP、DBP均低于对照组,P<0.05。治疗前两组患者肾功能情况无差异,P>0.05;治疗后观察组尿微量清蛋白(Urinary microalbumin,MAU)、血尿素氮(Blood urea nitrogen,BUN)以及血肌酐(serum creatinine,SCr)水平明显低于对照组,P<0.05。对照组、观察组不良反应发生率分别为11.90%、9.52%,对比无差异,P>0.05。结论高血压早期肾损害患者采用依那普利联合乐卡地平治疗效果显著,有效改善患者血压及肾功能水平,安全性高,值得临床应用及推广。
Objective To study the clinical effect of enalapril combined with lereanidipine on hypertensive patients with early renal damage. Methods 84 hypertensive patients with early renal damage treated in our hospital from June 2013 to June 2015 were clinically involved. All cases were divided into control group and observation group according to random number table, with 42 eases in each group. 42 patients were treated with enalapril only as the control group, the other 42 patients were given lereanidipine combined with enalapril as observation group. Curative effect, renal function and adverse reactions between two groups were observed. Results The total effective rate in the observation group and eontrol group was 95.24%and 78.57% respectively, the value in the observation group was higher than that in control group, P 〈0.05. The SBP,DBP between two groups had no difference before treatment, P 〉0.05; The SBP,DBP at the observation group were both lower than that in control group after treatment, P 〈0.05. The renal function between two groups had no difference before treatment, P〉0.05; The level of MAU,BUN and SCr at observation group was evidently lower than those at control group after treatment, P〈0.05. The adverse reactions incidence of the control and observation group was 11.90% and 9.52% respectively, which had no difference, P〉0.05. Conclusion Enalapril combined with lercanidipine on hypertensive patients with early renal damage, had remarkable effect, which can effectively improve blood pressure and renal function of patients, has high-security and is worth clinical application and promotion.
出处
《新疆医学》
2016年第8期977-979,共3页
Xinjiang Medical Journal
关键词
高血压
肾损害
依那普利
乐卡地平
疗效
Hypertension
Renal damage
Enalapril
Lercanidipine
Curative effect
