摘要
[目的]探讨肿瘤细胞减灭术联合腹腔热灌注化疗对胃癌腹膜转移患者的治疗效果及生活质量的影响。[方法]对86例胃癌腹膜转移患者的临床资料进行回顾性分析,根据患者所开展的治疗方式的不同分为观察组45例及对照组41例。观察组患者行肿瘤细胞减灭术联合腹腔热灌注化疗,对照组患者行肿瘤细胞减灭术及常规静脉注射全身化疗。对两组患者细胞减灭程度、术后并发症、化疗不良反应、1年生存率以及生活质量进行观察与比较。[结果]观察组患者肿瘤细胞减灭程度0级患者占80.00%,对照组70.73%,两者差异无统计学意义(P>0.05)。观察组患者术后并发症发生率为17.78%,对照组17.07%,两组相较差异无统计学意义(P>0.05)。观察组患者腹胀、腹泻发生率明显高于对照组,而白细胞减少及血小板减少发生率明显低于对照组,差异均具有统计学意义(P<0.05)。两组患者治疗后生活质量评分比较结果显示,观察组患者躯体功能及总体状况得分明显优于对照组,差异具有统计学意义(P<0.05)。观察组患者1年生存率为64.44%,远高于对照组31.71%,差异具有统计学意义(P<0.05)。[结论]肿瘤细胞减灭术联合腹腔热灌注化疗对胃癌腹膜转移患者具有良好的治疗效果及安全性,对于患者生活质量改善及生存率提高有积极意义,值得在排除相关禁忌证的患者中推广应用。
[Objective] To evaluate the clinical efficacy and quality of life in gastric cancer patients with peritoneal metastasis treated by cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy. [Methods] Clinical data of 86 gastric cancer patients with peritoneum metastasis was analyzed retrospectively,including 45 cases treated by cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy（study group） and 41 cases treated by cytoreductive surgery combined with conventional chemotherapy（control group）. The reductive rate,postoperative complications,adverse effects,1-year survival rate and quality of life were compared between two groups. [Results] There were no significance differences in grade 0 cytoreductive rate and complication rate between two groups（80.00% vs 70.73%,P〉0.05;17.78% vs 17.07%,P〉0.05,respectively）. The incidence of abdominal distention and diarrhea in study group were significantly higher than that in control group,but the incidence of leukopenia and thrombocytopenia in study group was significantly lower than that in control group（both P〈0.05）. The scores of body function and general performance in study group were significantly higher than those in control group（both P〈0.05）. The 1-year survival rate in study group was higher than that in control group（64.44% vs 31.71%,P〈0.05）. [Conclusion] Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy have superior efficacy and safety in treatment of gastric cancer with peritoneum metastasis,and it also improves survival rate and quality of life of the patients.
出处
《肿瘤学杂志》
CAS
2016年第9期718-721,共4页
Journal of Chinese Oncology
关键词
肿瘤细胞减灭术
腹腔热灌注化疗
胃肿瘤
腹膜转移
疗效
生活质量
cytoreductive surgery
hyperthermic intraperitoneal chemotherapy
gastric neoplasms
peritoneum metastasis
efficacy
quality of life
