摘要
目的探究氯沙坦、缬沙坦两种血管紧张素Ⅱ受体拮抗剂干预高血压患者尿酸代谢的临床效果。方法将我院2014年4月~2016年1月收治的70例患者按入院先后分为氯沙坦组（38例）、缬沙坦（32组）,分别采用氯沙坦和缬沙坦两种血管紧张素Ⅱ受体拮抗剂进行治疗。分别于治疗前、治疗后4周和治疗后8周三个时间段对两组患者的血尿酸及血压水平进行比较。结果随着治疗的进行,两组患者的SBP、DBP水平逐渐降低。在治疗后4周、8周,两组患者SBP、DBP水平比较,差异无统计学意义（P〉0.05）。治疗期间,氯沙坦组患者的血尿酸水平逐渐下降,而缬沙坦组患者的血尿酸水平则无明显变化。治疗后4周、8周,两组患者的血尿酸水平比较,差异有统计学意义（P〈0.01）。结论氯沙坦、缬沙坦两种血管紧张素Ⅱ受体拮抗剂降压效果相当,而氯沙坦能够改善高血压患者的尿酸代谢,显著降低其血尿酸水平。
Objective To explore the clinical effects of two kinds of angiotensin Ⅱ receptor antagonists liked losartan and valsartan in intervention uric acid metabolism in patients with hypertension.Methods 70 patients who treated in our hospital from April 2014 to January 2016 were divided into losartan group（38 cases） and valsartan group（32 cases）according to the admission order.Patients in two groups were respectively given two kinds of angiotensin Ⅱ receptor antagonists liked losartan and valsartan for treatment.The level of serum uric acid and blood pressure were respectively compared pretreatment,treatment for 4 weeks and after treatment for 8 weeks.Results With the treatment,the level of SBP and DBP in two groups gradually reduced.After treatment for 4 weeks and 8 weeks,the level of SBP and DBP between two groups had no statistical significance（P〉0.05）.During the treatment,the level of serum uric acid in losartan group gradually reduced,but the level of serum uric acid in valsartan group had no obvious changes.After treatment for4 weeks and 8 weeks,the level of serum uric acid between two groups had obvious difference（P〈0.01）.Conclusion The antihypertensive effect of two kinds of angiotensin Ⅱ receptor antagonists liked losartan and valsartan is equal,while losartan can improve the uric acid metabolism of hypertension patients and obvious decrease the level of serum uric acid.
出处
《中国当代医药》
2016年第26期124-126,共3页
China Modern Medicine
关键词
氯沙坦
缬沙坦
高血压
尿酸代谢
Losartan
Valsartan
Hypertension
Uric acid metabolism
