摘要
肌少症（sarcopenia）是与增龄相关的进行性、全身肌量减少和/或肌强度下降或肌肉生理功能减退,其与活动障碍、跌倒、低骨密度及代谢紊乱密切相关,是老年人生理功能逐渐减退的重要原因和表现之一。肌少症会增加老年人的住院率及医疗花费,严重影响老年人的生活质量,甚至缩短老年人的寿命。
Objective To investigate the changes of bone mineral density and bone turnover biomarker after dis- continuation of treatment when osteoporosis was improved, and to explore the best time to assess the changes of bone mineral density and bone turnover marker after drug withdrawal. Methods Collecting these osteoporotic out-patients （T ≤2. 5 ） from 2008 August to 2011 October in Shanghai First People＇s hospital treated with bisphosphonate more than or equal to 3 years. Group A ： assessment of patients after drug withdrawal for 6 months （ n = 62） ; Group B ： assessment of patients after drug withdrawal for 12 months （ n = 55 ） ; Group C ： assessment of patients after drug withdrawal for 6 months and 12 months （n = 17 ）. All clinical data included the age, body mass index （BMI） , treatment time, bone mineral den- sity （BMD）, serum calcium, serum phosphorus, serum 25 hydroxyvitamin D （25-OHD）, bone gamma-carboxyglutamic- acid-containing proteins （BGP） , type I collagen cross-linked carboxy terminal peptide （CTX） and so on at the end of therapy and after discontinuation. Results Group A： compared to baseline, the lumbar vertebrae, femoral neck and to- tal hip bone mineral densities were decreased after drug withdrawal for 6 months （ P 〈 0.05 ） ; But the changes were less than the least significant change （LSC） , then these changes had no clinical significance. Group B ： compared to baseline, the lumbar vertebrae, total hip bone mineral densities were significantly decreased after drug withdrawal for 12 months （P 〈0. 05）. After drug withdrawal for 6 months and 12 months, bone mineral densities of lumbar spine, femoral neck and hip were decreased. Compared to baseline, bone turnover markers （BTM） were increased significantly （ P 〈 0. 05 ）. Conclusion Assessment of bone mineral density and bone turnover after discontinuation of bisphosphonate for 12 months is advantageous to early prediction and assessment of the outcome.
出处
《中华骨质疏松和骨矿盐疾病杂志》
2016年第3期228-235,共8页
Chinese Journal Of Osteoporosis And Bone Mineral Research
