期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

乳腺型肌纤维母细胞瘤临床病理分析 被引量：2

下载PDF
导出
摘要 目的探讨乳腺型肌纤维母细胞瘤的临床病理特征和鉴别诊断要点。方法收集12例乳腺型肌纤维母细胞瘤,对其临床特征、组织形态学特点、免疫表型以及预后进行观察并结合文献进行分析。结果 4例发生于乳腺,5例发生于腹股沟区（1例外阴,1例腹股沟,3例阴囊周）,2例位于下肢,1例位于胸壁。大体上肿瘤界限相对清楚,部分带包膜,切面灰白灰褐至淡黄色,质地较均匀,部分有光泽;镜下肿瘤由温和的梭形细胞和粗大的胶原纤维束以及不同比例的脂肪细胞构成,3例（25%）可见局灶的非典型退变型核,2例可见核分裂像约1~2个/50高倍镜视野,4例（33%）局灶区瘤细胞呈上皮样形态表现;免疫组化染色,12例肿瘤（100%）均表达CD34和Desmin。结论乳腺型肌纤维母细胞瘤是一种好发于乳腺和腹股沟区的良性软组织肿瘤,组织形态上具有较大的异质性,免疫组化染色可帮助诊断和鉴别诊断。
作者 邵畅 齐广伟 过华蕾
机构地区 杭州市第一人民医院 杭州市儿童医院 杭州市妇产科医院
出处 《浙江实用医学》 2016年第4期293-295,共3页 Zhejiang Practical Medicine
关键词 肌纤维母细胞瘤 乳腺型 良性 软组织肿瘤 鉴别诊断
分类号 R730.26 [医药卫生—肿瘤]
  • 相关文献

参考文献8

  • 1Fletcher CD, Bridge JA, Hogondoorn PC, et al. WHO classification of tumours of soft tissue and bone. Lyon: IRAC, 2013, 61.
  • 2Wargotz ES, Weiss SW, Norris H]. Myofibroblastoma of the breast. Sixteen cases of a distinctive benign mesenchymal tumor. Am J Surg Pathol, 1987,11:493.
  • 3McMenamin ME, Fletcher CD. Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma . Am J Surg Pathol,2001,25:1022.
  • 4Magro G. Mammary myofibroblastoma: a tumor with a wide morphologic spectrum. Arch Pathol Lab Med,2008,132:1813.
  • 5Maggiani F, Debiec-Rychter M, Verbeeck G, et al. Extra- mammary myofibroblastoma is genetically related to spindle cell lipoma. Virchows Arch,2006,449:2d4.
  • 6Chen B J, Marino-Enriquez A, Fletcher CD, et al. Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: an immunohisto- chemical study with diagnostic implications. Am J Surg Pathol, 2012,36:1119.
  • 7宫丽华,田萌萌,佟桂珍,丁宜,黄啸原.梭形细胞/多形性脂肪瘤7例临床病理分析[J].临床与实验病理学杂志,2016,32(2):157-160. 被引量：4
  • 8Doyle LA, Vivero M, Fletcher CD, et al. Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Mod Pathol,2014,27:390.

二级参考文献12

  • 1Fletcher C D, Martin-Bates E. Spindle cell lipoma: a clinicopath- ological study with some original observations[ J ]. Histopathology, 1987,11 (8) :803 - 17.
  • 2Billings S D, Folpe A L. Diagnostically challenging spindle cell li- pomas: a report of 34 "low-fat" and "fat-free" variants[J]. Am J Dermatopathol, 2007,29 ( 5 ) :437 - 42.
  • 3Enzinger F M, Harvey D A. Spindle cell lipoma[J]. Cancer,1975,36(5) :1852 -9.
  • 4Enzinger F M. Management of primary bone and soft tissue tumors. Benign lipomatous tumors simulating a sarcoma[ M]. Chi- cago : Year Book Medical, 1977 : 11 - 24.
  • 5Fletcher C D, Bridge J A, Hogendoorn P C. World Health Organi- zation classification of tumours of soft tissue and bone[ M]. Lyon: IARC Press, 2013:255 -6.
  • 6Beham A, Schmid C, Hfidl S, et al. Spindle cell and pleomorphic lipoma: an immunohistochemical study and histogenetic analysis [J]. J Pathol, 1989,158(3) :219 -22. .
  • 7Fanburg-Smith J C, Devaney K O, Miettinen M, et al. Multiple spindle cell lipomas : a report of 7 familial and 11 nonfamilial cases [J]. Am J Surg Pathol, 1998,22(1) :40 -8.
  • 8Shmookler B M, Enzinger F M. Pleomorphic lipoma: a benign tumor simulating liposarcoma. A clinicopathologic analysis of 48 cases[ J]. Cancer, 1981,47 ( 1 ) : 126 - 33.
  • 9Syed S, Martin A M, Hanpt H, et al. Frequent detection of an- drogen receptors in spindle cell lipomas : an explanation for this le- sion' s male predominance [ J ] ? Arch Pathol Lab Med, 2008,132 (1) :81 -3.
  • 10Chen B J, Mariuo-Enuquez A, Fletcher C D, et al. Loss of retino- blastoma protein expression in spindle eell/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical study with diagnostic implications [ J ]. Am J Surg Pathol, 2012,36 ( 8 ) : 1119 -28.

共引文献3

同被引文献6

引证文献2

浙江实用医学
2016年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部