摘要
目的探讨窄谱中波紫外线联合消银颗粒与盐酸左西替利嗪片治疗玫瑰糠疹的临床分析。方法选自杭州市第三人民医院2014年3月至2015年9月期间收治的玫瑰糠疹患者94例,依据随机数字表法随机分为观察组47例与对照组47例。对照组采用消银颗粒联合盐酸左西替利嗪片治疗,观察组在对照组基础上窄谱中波紫外线治疗。两组均以2周为1疗程,连续观察2个疗程。比较两组治疗疗效、PRSS评分、血清炎症因子及不良反应发生情况。结果观察组总有效率(95.73%)高于对照组(78.72%)(P<0.05);两组PRSS评分治疗后明显减少(P<0.05);观察组PRSS评分治疗后低于对照组(P<0.05);观察组红斑消失时间和瘙痒症状消失时间明显优于对照组(P<0.05);两组血清IL-4水平治疗后明显增加,IL^(-1)2和TNF-α治疗后明显降低(P<0.05);观察组血清IL-4水平治疗后高于对照组,IL^(-1)2和TNF-α治疗后低于对照组(P<0.05);两组患者均未见严重不良反应。结论窄谱中波紫外线联合消银颗粒与盐酸左西替利嗪片治疗玫瑰糠疹临床疗效显著,安全可靠。
Objective To explore the effect of NB-UVB combined with Xiaoyin granules and levocetirizine hydrochloride tablets on pityriasis rosea. Methods 94 cases of pityriasis rosea were selected from our hospital between March 2014 and September 2015 and randomly divided into observation group（ 47 cases） and control group（ 47 cases）. The control group was treated with Xiaoyin granules combined with levocetirizine hydrochloride tablets while the observation group was treated the same way as the control group plus NB-UVB treatment. The course of treatment was two weeks for both groups followed by one more courses of observation. The therapeutic efficacy,PRSS score,serum inflammatory factors and adverse reactions were compared between the two groups. Results The total effective rate of the observation group（ 95. 73%） was higher than that of the control group（ 78. 72%）（ P 〈0. 05）. PRSS scores in both groups were significantly reduced（ P 〈 0. 05）. After treatment,the PRSS score of the observation group was lower than that of control group（ P 〈 0. 05）. Symptoms of the observation group disappeared more quickly than those of the control group（ P 〈 0. 05）. The serum levels of IL-4 in both groups were significantly increased,so were IL-12 and TNF-α（ P 〈 0. 05）. The serum IL-4 level in the observation group was higher than that in the control group,but the level of IL-12 and TNF-α was lower than that of the control group（ P 〈 0. 05）.No serious adverse reactions were found in either group. Conclusion NB-UVB combined with Xiaoyin granules and levocetirizine hydrochloride tablets is quite effective,safe and reliable in the treatment of pityriasis rosea.
作者
宋子君
王涛
SONG Zi-jun WANG Tao(Department of Pharmacy,Hangzhou Third People＇s Hospital,Hangzhou 310009, China)
出处
《解放军药学学报》
CAS
CSCD
2016年第4期380-382,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
