摘要
溶血磷脂酸(LPA)是一种广泛存在的生物活性磷脂,参与调节细胞的多种生物学行为。研究表明,LPA可以通过特定的G蛋白耦联受体(GPCRs)调控细胞的增殖、分化、迁移和侵袭等生物学行为。已有研究表明,肿瘤的恶化及干细胞介导的组织修复与细胞迁移能力紧密相关。鉴于LPA对肿瘤细胞及干细胞迁移能力的显著影响,本文主要从LPA受体和受体下游主要信号分子两个方面介绍了LPA对肿瘤细胞和干细胞迁移行为的影响及其相关分子机制。
Lysophosphatidic acid （LPA） is a pluripotent lipid mediator and acts via different G-protein-couple LPA receptors. LPA has significant effects on several cellular biological behaviours, such as cell migration, invasion, proliferation and differentiation, etc. Cell migration is essential for tumor progression, and vital for stem cell to repair injured tissues. Increasing evidences have demonstrated that LPA dramatically affects migration capacity of various cells, particularly cancer cells and stem cells. In this paper, we review the effect of LPA on migration of cancer cells and stem cells, and discuss the underlying mechanisms. A better understanding of this process will shed new light on tissue regeneration and the prevention of tumor progression.
作者
林川川
李铎
李佳文
宋关斌
LIN Chuanchuan LI Duo LI Jiawen SONG Guanbin(College of Bioengineering, Chongqing University, Chongqing 400044, Chin)
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2016年第5期1005-1010,共6页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(11272365
11532004)
高等学校博士学科点专项科研基金资助项目(20130191110029)
中央高校基本科研业务费资助项目(106112015CDJZR238807)
国家级大学生创新训练资助项目(201510611045)
关键词
溶血磷脂酸
溶血磷脂酸受体
细胞迁移
分子机制
lysophosphatidic acid
lysophosphatidic acid receptor
cell migration
molecular mechanism
