摘要
目的检测IMP3、EGFR、P53蛋白在神经胶质瘤组织中的表达,研究其与患者预后的关系。方法收集胶质瘤标本185例和20例因脑血管畸形手术切除的正常脑组织,采用免疫组化S-P二步法检测IMP3、EGFR和P53的表达情况,并结合患者生存时间进行统计学分析。结果 IMP3、EGFR和P53在对照组中表达极低,在胶质瘤组织高级别组中表达水平均明显高于低级别组。且三者表达呈显著正相关。单因素及COX多因素模型分析表明,IMP3的表达可作为患者预后的独立危险因素,EGFR的表达对患者预后存在一定影响,但不可作为预后独立危险因素。结论IMP3、EGFR和P53的联合检测可能成为胶质瘤生物标记的新指标,IMP3、EGFR可能成为脑胶质瘤治疗的特异靶点。
Objective To investigate the expressions and clinical significance of IMP3,EGFR and P53 protein in glioma.Methods Expression of IMP3,EGFR and p53 were analyzed by S-P immunohistochemsitry in 185 cases of gliomas and 20 cases of normal brain tissues.Kaplan-Meier and multivariate analysis of Variance was used to analysis the survival rate of patients with gliomas.Results Positive expression rate of IMP3,EGFR and P53 in glioma tissue were higher than those in normal brain tissue.The expression rate of IMP3,EGFR and p53 were positively correlated with the pathologic stage.Meanwhile,there was a significantly positive correlation between IMP3,EGFR and IGF2.Histological grading and expression of IMP3 were the independent risk factors of prognosis of glioma,there was a certain effect on the prognosis of patients for EGFR,but it is not an independent risk factor for prognosis.Conclusions Combined detection of IMP3,EGFR and P53 may be new markers of glioma,and IMP3 and EGFR might be possible novel targets for molecular treatment of gliomas.
作者
谢欣
褚明亮
陈祎
张著学
杨迎春
易韦
于燕妮
Xie Xin Chu Mingliang Chen Yi Zhang Zhuxue Yang Yingchun Yi Wei Yu Yanni(Guizhou Medical University, Guiyang 550004, Guizhou, China People＇s Hospital of Guizhou Medical University, 550002, Guizhou, China.)
出处
《贵州医药》
CAS
2016年第8期794-797,共4页
Guizhou Medical Journal
基金
贵州省科技厅基金资助课题(黔科合字LH[2014]7017号)
