摘要
目的分析肺结核初治患者化疗期间发生肝损害的相关因素。方法采用历史性列队研究,回顾性分析2010年3月-2014年12月初治肺结核病历资料592例,采用单因素χ2检验(P<0.05)和非条件Logistic回归模型对抗结核药物所致肝损害的相关因素进行分析。结果肺结核患者化疗引起肝损害的危险因素为性别(OR=0.166 CI 0.062-0.442)、年龄(OR=2.209 CI 1.468-3.326)、饮酒史(OR=2.165CI1.338-3.503)、营养状况(OR=2.555 CI 1.399-4.665)、HBV感染者(OR=3.13 CI 1.61-6.085)、未使用护肝药物((OR=6.349 CI 3.562-11.319)、未使用免疫药物(OR=3.614 CI 1.986-6.576)结论男性、高龄、营养不良、嗜酒、HBV感染、未使用护肝和免疫药物,是抗结核药物性肝损害的危险因素。
Objective To analyze the risk factors associated with anti-tuberculosis drug-induced liver injury in initial-treated patients with pulmonary tuberculosis. Methods Using historic parade study, a retrospective analy-sis of 620 patients with pulmonary tuberculosis was conducted from March 2010 to December 2014. It used a single factorχ2 test （P〈0. 05） and non-conditional Logistic regression model to analyze the related factors of anti-TB drug-induced liver damage. Results The risk factors of liver damage caused by chemotherapy in patients with pulmonary tuberculosis included gender （OR=0. 166, CI0. 062 -0. 442）, age （OR=2. 209, CI1. 468 -3. 326）, history ofalcoholism （OR=2. 165, CI1. 338 -3. 503）, nutritional status （OR=2. 555, CI1. 399 -4. 665）, HBV infection （OR=3. 13, CI1. 61-6. 085）, unused liver drugs （OR=6. 349, CI3. 562-11. 319）, and without immune drugs （OR=3. 614, CI1. 986-6. 576）. Conclusion The risk factors of liver damage in patients with pulmonary tubercu-losis include male, age, malnutrition, alcoholism, HBV infection, unused liver drugs, and without immune drugs.
出处
《临床肺科杂志》
2016年第11期2097-2100,共4页
Journal of Clinical Pulmonary Medicine
关键词
肺结核
化疗
肝损害
相关因素
pulmonary tuberculosis
chemotherapy
liver damage
related factors
