摘要
目的:观察清肺通络汤治疗卒中后多重耐药菌感染肺炎的临床疗效。方法:纳入79例脑卒中后多重耐药菌感染肺炎患者,随机分为治疗组40例和对照组39例。对照组给予常规脑卒中治疗,同时依据痰培养给予相应抗感染治疗;治疗组在对照组基础上给予清肺通络汤加减口服治疗。两组治疗周期均为14 d。评价两组患者的临床疗效及细菌学疗效,检测并比较两组患者的白细胞计数(WBC)、C反应蛋白(CRP)及降钙素原(PCT)水平。结果:治疗后,治疗组的总有效率为90.0%,对照组为59.0%,两组临床疗效比较差异有统计学意义(P<0.05)。治疗后,两组患者的致病菌清除情况比较,差异无统计学意义(P>0.05);两组患者的WBC、CRP水平较治疗前均明显降低(P<0.05),且治疗组患者的WBC、CRP水平低于对照组(P<0.05);治疗组患者的PCT水平较治疗前明显降低(P<0.05),且治疗组患者的PCT水平低于对照组(P<0.05)。结论:清肺通络汤结合西医常规疗法治疗卒中后多重耐药菌感染肺炎,具有良好的临床效果,值得在临床中推广。
Objective： To evaluate the therapeutic effect of ＂Qingfei Tongluo Decoction＂ in treating patients with stroke associated pneumonia （SAP） of multiple drug-resistant bacterial infection. Methods： Seventy-nine patients with SAP of multiple drug-resistant bacterial infection were selected and randomly divided into the treatment group （40 cases ） and the control group （39 cases）. The patients in the control group were treated with conventional therapy of stroke, meanwhile the anti-infective therapy was applied according to the results of sputum culture ; the patients in the treatment group were treated with ＂Qingfei Tongluo Decoction＂ based on the therapy of the control group. The treatment course was 14 days. The clinical effect and the bacteriological effect were evaluated, and the levels of white blood cell （WBC） , C reactive protein （CRP） and procalcitonin （PCT） were detected and compared. Results ： After treatment, the total effective rates of the treatment group and control group were 90.0% and 59.0% respectively, with statistical difference between the two groups （ P 〈 0.05 ）. There was no statistical difference between the two groups on the bacteriological effect （ P 〉 0.05 ）. After treatment, the levels of WBC and CRP in both groups were significantly decreased （ P 〈 0.05 ）, and the levels of WBC and CRP of the treatment group were lower than those of the control group （ P 〈 0. 05 ） ; the level of PCT of the treatment group was obviously decreased （ P 〈 0.05 ） , and the level of PCT of the treatment group was lower than that of the control group （ P 〈 0.05 ）. Conclusion ： ＂Qingfei Tongluo Decoction＂ combined with conventional western medicine have good effect in treating patients with SAP of multiple drug-resistant bacterial infection and are worthy of population in clinic.
出处
《上海中医药大学学报》
CAS
2016年第5期26-29,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
关键词
清肺通络汤
卒中相关性肺炎
中西医结合疗法
多重耐药菌感染
＂ Qingfei Tongluo Decoction＂
stroke associated pneumonia
therapy of integrated Chinese and western medicine
multiple drug-resistant bacterial infection
