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Skp2与其底物CDKN1B(p27)在结直肠癌中的作用 被引量：6

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摘要 结直肠癌(colorectal cancer,CRC)是全球高发恶性肿瘤之一,居癌症患者致死第4位。对结直肠癌的发生、发展中的信号通路和与之相关的细胞因子的相关研究较多。S期激酶相关蛋白2(S-phase kinase-associated protein 2,Skp2)的过表达在结直肠癌的发生与发展的过程中扮演至关重要的角色。F-box蛋白Skp2是Skp1-Cullin 1-F-box(SCF)泛素连接酶(E3)复合物的组成元件,具有调节细胞增殖的作用,同时能通过调控多种细胞周期的泛素化和26S蛋白酶体降解来调控肿瘤细胞的进展与转移。Skp2与其蛋白基质细胞周期蛋白依赖性激酶抑制剂1B(cyclin-dependent kinase inhibitor 1B,CDKN1B),也被称为p27kip1间通过SCF-Skp2复合体和细胞周期蛋白依赖性激酶亚基1(cyclin-dependent kinase subunit 1,Cks1)辅因子的激活而进行有效的链接。Skp2的过表达、Cks1和CDKN1B(p27)表达的变化对结直肠癌的发生、发展起到重要的作用,三者可能是结直肠癌独立的预后指标。Skp2可能是结直肠癌治疗中有前景的靶标,其抑制剂的研发对结直肠癌的治疗起关键性作用。本文将对Skp2与其泛素-蛋白酶体途径在结直肠癌中的作用进行综述。
作者 李云霄(综述) 许新华(审校)
机构地区 三峡大学第一临床医学院
出处 《实用肿瘤杂志》 CAS 2016年第5期478-482,共5页 Journal of Practical Oncology
关键词 结直肠肿瘤/病理生理学 S期激酶相关蛋白质类/代谢 细胞周期蛋白质类/代谢 肿瘤抑制蛋白质类/代谢 免疫组织化学 综述
分类号 R735.3 [医药卫生—肿瘤] R730.23 [医药卫生—肿瘤]
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参考文献27

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二级参考文献32

  • 1马秀梅,刘江惠,郭建文,刘颖,左连富.胃癌组织Skp2表达的意义及与p27表达的关系[J].实用肿瘤杂志,2006,21(1):24-28. 被引量：3
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实用肿瘤杂志
2016年 第5期

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