慢性阻塞性肺疾病急性加重期住院患者病毒感染危险因素分析被引量：30

Risk factors of virus infection in patients with acute exacerbations of chronic obstructive pulmonary disease in hospital

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摘要目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)住院患者病毒感染的危险因素,为临床预防治疗AECOPD患者病毒感染提供依据。方法选择2011年1月-2014年12月接受治疗150例AECOPD患者作为研究对象,采取酶联免疫法(ELISA)进行病毒检测,分析患者病毒感染的危险因素。结果对150例AECOPD患者进行病毒检测,发现其中有52例患者病毒检测结果呈阳性,阳性率为34.67%;以单一病毒感染为主,占73.08%,其中鼻病毒(hRV)是AECOPD患者最主要的感染病毒,占23.68%;呼吸障碍、糖尿病及哮喘为患者病毒感染的相关因素,差异有统计学意义(P<0.05);呼吸障碍、糖尿病及哮喘是引发AECOPD患者病毒感染的主要因素,差异有统计学意义(P<0.05);病毒感染患者的舒张压显著高于未感染患者(P<0.05),其他呼吸状况、血常规检查及常规化验检测等临床指标的差异均无统计学意义。结论 hRV是AECOPD患者最主要的感染病毒,控制血糖和戒烟对降低AECOPD病毒感染,明确接种病毒疫苗可以大幅度降低AECOPD病毒感染的病情恶化;AECOPD住院患者病毒感染危险因素分析对于AECOPD疾病的临床管理和预防治疗具有重要指导意义。 OBJECTIVE To explore the risk factors of virus infection in patients with acute exacerbation of chronic obstructive pulmonary disease in hospital,so as to provide the basis for the prevention and treatment of the virus infection.METHODS A total of 150 cases with AECOPD who were treated in respiratory medicine from Jan.2011 to Dec.2014 were recruited as the study objects,virus were detected by taking ELISA technology,and the risk factors of viral infection in patients were analyzed.RESULTS Of 150 patients with virus detection,52 cases were positive with virus detection result,and the positive rate was 34.67%.The single virus infection was mainly with the proportion of 73.08%,and the detection rate of the hRV was the highest with the proportion of 23.68%.Respiratory disorders,diabetes and asthma were related factors of infection,and the differences were significant（P〈0.05）.Respiratory disorder,diabetes and asthma were the main factors for causing virus infection in AECOPD patients,and the differences were significant（P〈0.05）.The diastolic blood pressure in virus infected patients was significantly higher than the uninfected patients（P=0.02,P〈0.05）,and the differences of the clinical indicators were not significant,such as other respiratory condition,blood routine examination and routine assay.CONCLUSIONhRV was the main infection virus in patients with AECOPD,it was important to control the blood sugar to reduce the risk factors of virus infection,and it was clear that the virus vaccine could reduce greatly the deterioration of virus infections.The risk factors analysis of virus infection in patients with AECOPD had an important guiding significance to the clinical management,prevention and treatment of AECOPD disease.

作者陈晓何和章林容陈亚芳黎健

机构地区三亚市人民医院呼吸内科三亚市人民医院老年病科三亚市人民医院检验科

出处《中华医院感染学杂志》 CAS CSCD 北大核心 2016年第19期4452-4454,共3页 Chinese Journal of Nosocomiology

基金海南省重点科技基金资助项目(ZDXM20120055)

关键词慢性阻塞性肺疾病急性加重期病毒感染危险因素分析 AECOPD Virus infection Risk factors analysis

分类号 R563 [医药卫生—呼吸系统]

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