摘要
目的探讨血清癌抗原125(CA125)和人附睾蛋白4(HE4)联合盆腔磁共振成像(MR)检查在子宫内膜癌中的临床价值。方法选取该院收治的子宫内膜病变患者96例,分为子宫内膜癌组56例,子宫内膜不典型增生组40例;另选取同期因子宫肌瘤切除子宫的增生期和分泌期子宫内膜组20例为对照组。检测3组的血清CA125和HE4水平,并行盆腔MR检查,对比三者单独或联合检查的灵敏度及特异度。结果子宫内膜癌组血清CA125和HE4水平高于子宫内膜不典型增生组和对照组,子宫内膜不典型增生组血清CA125和HE4水平高于对照组,晚期子宫内膜癌组的血清CA125和HE4水平高于早期子宫内膜癌组,差异均有统计学意义(P<0.05)。CA125、HE4联合盆腔MR检查对子宫内膜癌诊断的灵敏度、特异度及准确性均高于其他指标,差异有统计学意义(P<0.05)。结论血清CA125和HE4是评估子宫内膜癌病情进展情况的重要指标,CA125和HE4联合盆腔MR检查可提高子宫内膜癌诊断的灵敏度和特异性,具有重要的临床参考价值。
Objective To investigate the clinical value of serum cancer antigen 125（ CA125） and human epididymis protein 4（ HE4） combined with pelvic magnetic resonance imaging（ MR） in endometrial carcinoma. Methods To Select 96 cases of patients with endometrial lesions in the hospital,56 cases of endometrial carcinoma group,40 cases of endometrial atypical hyperplasia group; Other select the same period because of myoma of uterus excision uterus hyperplasia period and secretory phase endometrium group 20 cases as control group. Detection of three groups of serum CA125 and HE4 levels,parallel pelvic MR,compared sensitivity and specificity to three separate or joint inspection. Results In endometrial carcinoma group,the serum levels of CA125 and HE4 is higher than endometrial atypical hyperplasia group and control group. In endometrial atypical hyperplasia group,the serum levels of CA125 and HE4 is higher than control group. The levels of CA125 and HE4 in advanced endometrial carcinoma group is higher than that of early endometrial carcinoma group,the differences are statistically significant（ P 〈 0. 05）. CA125,HE4 combined with pelvic MR in diagnosis of endometrial carcinoma,the sensitivity,specificity and accuracy are higher than other indicators,and the difference is statistically significant（ P 〈 0. 05）. Conclusion Serum CA125 and HE4 are important index to evaluate the progression of endometrial carcinoma. CA125 and HE4 combined with pelvic MR examination can improve the sensitivity and specificity of the diagnosis of endometrial carcinoma and has an important clinical reference value.
出处
《医药论坛杂志》
2016年第9期18-20,共3页
Journal of Medical Forum
