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CCT2在肝细胞癌中的表达及意义

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摘要 目的探讨Chaperonin containing TCP1,subunitβ(CCT2)在肝细胞癌中的表达及临床意义。方法采用免疫组织化学方法对73例肝细胞癌组织和癌旁组织行CCT2检测,并结合临床病理参数及Ki-67进行分析。结果 CCT2在肝细胞癌组织中的高表达率高于癌旁组织(P<0.01),在低分化组中的高表达率高于中高分化组(P<0.01),并且CCT2的表达与Ki-67的表达呈正相关(P<0.01)。结论 CCT2在肝细胞癌组织中具有较高表达,其过表达与肝细胞癌的发生发展可能密切相关,这为CCT2可能成为肝细胞癌靶向治疗的潜在靶点提供了理论依据。
机构地区 南通市肿瘤医院
出处 《基层医学论坛》 2016年第25期3551-3552,共2页 The Medical Forum
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