摘要
氧疗是临床常见的治疗手段,危重患者伴顽固性低氧血症时常常需要高氧治疗,而长久吸入高浓度氧时,易致肺结构及功能异常,高氧性急性肺损伤(HALI)是氧疗最典型的并发症。HALI发病机制尚不完全明确,多数学者认为氧化-抗氧化系统、致炎-抗炎系统的失衡是导致HALI的主要原因,近些年来研究认为细胞凋亡是HALI的重要组织学特点及潜在机制,在其发病过程中具有非常重要的作用,从凋亡角度深入研究HALI已成为热点。本文主要就HALI肺组织细胞凋亡的特点、诱发因素及其分子调控机制的最新研究进展进行综述。
Oxygen therapy is a clinically common treatment. When critically ill patients with refractory hypoxemia,often required hyperoxia treatment,inhaled high concentration oxygen for a long time,it will cause abnormal structure and function of lung tissue. Hyperoxia- induced acute lung injury（ HALI） is the most typical syndrome of oxygen therapy and its exact pathogenesis is still unknown. Most scholars believe that the imbalance of oxidation- antioxidant system and inflammatory- anti- inflammatory system are the major reasons of HALI. In recent years,studies showed that cell apoptosis was an important part of the histological characteristics of HALI and underlying mechanisms and played the important role in HALI＇s pathogenesis. Therefore,doing HALI research from the perspective of apoptosis has become a hot spot way. This article mainly reviews that HALI lung tissue apoptosis＇ s characteristics,reasons and its latest research progress of hematopoietic regulatory mechanisms.
出处
《遵义医学院学报》
2016年第4期430-434,共5页
Journal of Zunyi Medical University
基金
国家自然科学基金资助项目(NO:8156010205)
遵义市科技支撑计划项目(NO:遵市科合社字[2014]60)
关键词
细胞凋亡
高氧
急性肺损伤
活性氧
分子调控机制
apoptosis
hyperoxia
acute lung injury
reactive oxygen species
hematopoietic regulatory mecha nisms
