摘要
目的探讨阿司匹林抗凝联合阿托伐他汀降血脂对治疗糖尿病动脉粥样硬化的临床疗效。方法选取2014年8月~2016年2月新疆库尔勒市巴州人民医院收治的糖尿病动脉粥样硬化患者120例为研究对象,随机分为治疗组与对照组,各60例,对照组患者给予阿司匹林肠溶片治疗,治疗组给予阿司匹林肠溶片联合阿托伐他汀治疗,对比2组治疗前后空腹血糖及血脂相关指标变化情况,及不良反应情况。结果治疗后,治疗组患者的空腹血糖（fasting blood glucose,FBG）、空腹胰岛素（fasting insulin,FINS）水平均显著低于对照组,差异有统计学意义（P〈0.05）,治疗组颈动脉内膜中层厚度及斑块厚度均显著低于对照组（P〈0.05）。治疗后治疗组患者的三酰甘油（triglyceride,TG）、总胆固醇（total cholesterol,TC）、低密度脂蛋白胆固醇（low-density lipoprotein cholesterol,LDL-C）及高密度脂蛋白胆固醇（high-density lipoprotein cholesterol,HDL-C）水平均显著改善,差异均有统计学意义（P〈0.05）。结论阿司匹林肠溶片联合阿托伐他汀治疗糖尿病动脉粥样硬化临床疗效显著。
Objective To investigate the effect of aspirin combined with atorvastatin in the treatment of diabetic atherosclerosis. Methods 120 patients with diabetic atherosclerosis form August 2014 to February 2016 were selected,and randomly divided into treatment group and control group,60 cases in each group. Control group treated with aspirin enteric-coated tablets,the treatment group treated with aspirin enteric-coated tablets combined with atorvastatin,comparing the two groups before and after treatment of fasting blood glucose,blood lipid related index,carotid intima-media thickness and plaque thickness,and the adverse reactions. Results After treatment,the levels of fasting blood glucose and fasting insulin in treatment group were significantly lower than control group（ p〈0. 05）,the carotid intima-media thickness and plaque thickness in treatment group was significantly lower than control group（ p〈0. 05）. The levels of TG,TC,LDL-C and HDL-C in treatment group were significantly improved（ p〈0. 05）. Conclusion Aspirin enteric coated tablets combined with atorvastatin efficacy significantly in the treatment of diabetic atherosclerosis.
出处
《中国生化药物杂志》
CAS
2016年第8期116-118,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
糖尿病
动脉粥样硬化
阿司匹林肠溶片
阿托伐他汀
临床疗效
diabetes mellitus
atherosclerosis
aspirin enteric-coated tablets
atorvastatin
clinical curative effect
