摘要
目的观察并研究奥曲肽联合奥美拉唑治疗肝硬化上消化道出血患者的临床疗效。方法选取2013年1月~2014年12月期间在余姚市人民医院消化内科收治的76例肝硬化上消化道出血患者随机分成观察组和对照组,每组各38例,在实验前均对2组患者均进行基础的对症治疗。对照组患者给予奥曲肽治疗,首次给药将0.1 mg奥曲肽溶于20 m L 0.9%Na Cl溶液后静脉推注,之后以25μg/h持续静脉滴注,维持72 h。观察组在对照组的基础上,将奥美拉唑40 mg溶于100 m L 0.9%Na Cl溶液,进行静脉滴注,2次/天,持续治疗3 d。分别观察2组患者的疗效、止血时间、输血量,以及治疗过程中患者的再出血和不良反应发生率。结果观察组总有效率89.47%显著高于对照组63.16%（P〈0.05）,观察组的显效率55.26%显著高于对照组31.58%（P〈0.05）;观察组的止血时间和输血量均显著小于对照组,且各项差异均具有统计学意义（P〈0.05）;此外,观察组的再出血发生率5.26%显著小于对照组21.05%（P〈0.05）;治疗过程中观察组和对照组中患者的不良反应发生率分别为10.53%和7.89%,两者差异无统计学意义。结论奥曲肽联合奥美拉唑治疗肝硬化上消化道出血,有利于缩短止血时间,减少输血量,减小再出血风险,能显著改善临床疗效。
Objective To observe and study the therapeutic effect of ctreotide combined with omeprazole in the treatment of liver cirrhosis with upper gastrointestinal bleeding. Methods 76 cases of patients with upper gastrointestinal bleeding caused by liver cirrhosis were selected in our hospital from January 2013 to December 2014 to be separated into the observation group and control group randomly,with each group having 38 patients. Patients in two groups were all given symptomatic treatment first. Patients in control group were given 0. 1 mg octreotide dissolved 20 m L 0. 9% sodium chloride solution by intravenous injection in the first administration. And the rest octreotide was given by intravenous drip at the speed of 25 μg / h. The treatment lasted for 72 h. On the base of control group,patients in observation group were given 40 mg omeprazole dissolved 100 m L 0. 9% sodium chloride solution additionally,twice daily,for 3 d. Then the therapeutic effect,hemostatic time,blood transfusion,rebleeding rate and adverse reactions of patients in two groups were observed. Results The total effective rate of observation group 89. 47% was much more than control group 63. 16%（ p〈0. 05）. And the apparent rate of observation group 55. 26% was also more than control group 31. 58%（ p〈0. 05）. Both the hemostatic time and blood transfusion of observation group is less than control group（ p〈0. 05）. Besides,the rebleeding rate of observation group 5. 26% is much less than control group21. 05%（ p〈0. 05）.,Incidence rates of adverse reactions in two groups were 10. 53% and 7. 89%,with no statistically significant difference.Conclusions Treatment of octreotide combined with omeprazole on patients with upper gastrointestinal bleeding caused by liver cirrhosis can improve the therapeutic effect,shorten the hemostatic time and decrease the blood transfusion with low rebleeding rate and few adverse reaction.
出处
《中国生化药物杂志》
CAS
2016年第8期127-129,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
奥曲肽
奥美拉唑
肝硬化
上消化道出血
临床疗效
octreotide
omeprazole
liver cirrhosis
upper gastrointestinal bleeding
therapeutic effect
