摘要
目的探讨桂枝茯苓丸对子宫内膜异位症（endometriosis,EMT）患者血清丝裂原活化蛋白激酶（mitogen-activated protein kinase,MAPK）、磷酸化细胞外信号调节激酶（phosphorylated extracellular signal-regulated kinase,p-ERK）、血管内皮生长因子（vascular endothelial growth factor,VEGF）表达的影响。方法选取2015年3月-2016年5月陕西省康复医院妇产科收治的126例EMT患者,将其随机分为观察组（n=63）和对照组（n=63）,2组均采用常规西药进行治疗,观察组同时服用桂枝茯苓丸,2组均治疗2个月。比较治疗前后2组血清MAPK、p-ERK和VEGF、肿瘤相关抗原125（tumor related antigen 125,CA125）水平及机体激素水平变化。结果治疗结束后,观察组血清MAPK、p-ERK、VEGF、CA125较对照组降低显著（P〈0.05）;观察组患者血清促卵泡激素（follicle stimulating hormone,FSH）、雌二醇（estradiol,E2）、孕酮（progesterone,P）水平较对照组降低明显（P〈0.05）,黄体生成素（luteinizing hormone,LH）水平在2组间差异无统计学意义;观察组盆腔包块直径较治疗前明显降低,且显著低于对照组（P〈0.05）。观察组治疗总有效率96.82%与对照组84.13%差异显著（P〈0.05）。结论桂枝茯苓丸能够抑制MAPK、p-ERK蛋白活性,降低VEGF表达水平,阻断细胞间信号传导通路以及细胞因子与表面受体的结合,从而使细胞分裂和子宫内膜异常增殖得以控制。
Objective To investigate the effect of Guizhi Fuling pills on the expressions of serum mitogen-activated protein kinase（MAPK）,phosphorylated extracellular signal-regulated kinase（p-ERK） and vascular endothelial growth factor（VEGF） in patients with endometriosis（EMT）.Methods 126 patients with EMs in Department of Obstetrics and Gynecology of Shaanxi Kangfu Hospital from March 2015 to May 2016 were randomly divided into observation group（n = 63） and control group（n = 63）. The 2 groups were treated with conventional western medicine,and observation group were combined with Guizhi Fuling pill. Both groups were treated for 2 months. Before and after treatment,serum MAPK,p-ERK,VEGF,tumor related antigen 125（CA125） and hormones between two groups were compared [re-and post-treatment. Results After treatment,the serum MAPK,p-ERK,VEGF and CA125 levels of observation group decreased significantly compared with control group（P〈0. 05）. The serum follicle stimulating hormone（FSH）,estradiol（E2） and progesterone（P） levels in observation group were significantly lower than those in control group（P〈0. 05）. There was no difference between 2 groups on the level of luteinizing hormone（LH）. The diameter of pelvic mass in observation group significantly reduced than before treatment,and significantly lower than the control group after treatment（P〈0. 05）. The total effective rate of observation group96. 82% and the control group 84. 13% was significantly different（P〈0. 05）. Conclusion Guizhi Fuling pill could inhibit protein activity of MAPK and p-ERK,reduce the expression of VEGF,block intercellular signaling pathway and connecting of cytokines with surface receptors,consequently,the cell division and the abnormal proliferation of the endometrium could be controlled.
出处
《中国生化药物杂志》
CAS
2016年第7期135-137,共3页
Chinese Journal of Biochemical Pharmaceutics
