摘要
阿尔茨海默病(Alzheimer disease,AD)是一种中枢神经退行性疾病,病因复杂。近年来研究发现,血管病变对AD有较大影响,血管内皮生长因子(vascular endothelial growth factor,VEGF)表达异常在患者病程中承担重要角色;同时AD患者脑内部分miRNA表达水平有明显变化。本文综述了血管病变及遗传因素对AD发生、发展的影响,并对可能的发病机制、相关治疗靶点及策略进行讨论与展望。
Alzheimer disease （AD） is a neurodegenerative disease of the central nervous system, with complicated etiologies. Recent studies have found that vascular disease has a great impact on AD, and abnormal vascular endothelial growth factor （VEGF） expression is thought to play an important role in the course of AD. MicroRNAs expression has greatly changed in the brain of AD patients. This paper reviewed the latest advance in the effects of vascular and genetic factors on the occurrence and progression of AD, with discussion also on the probable pathogenesis,therapeutic targets and strategies of AD.
作者
车皓月
王闰
单磊
潘勇华
高申
王忠壮
傅芃
CHE Hao-yue WANG Run SHAN Lei PAN Yong-hua GAO Shen WANG Zhong-zhuang FU Peng(Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China Department of Medicine, No. 85 Hospital of PLA, Shanghai 200050,China The Pharmacy Student Team, School of Pharmacy, Second Military Medical University, Shanghai 200433,China)
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2016年第10期1261-1269,共9页
Academic Journal of Second Military Medical University
基金
国家自然科学基金(81402819
81373327)
上海市自然科学基金(13ZR1408500)
总后勤部卫生部基金面上项目(14ZJ202-3)~~
