摘要
目的探讨冠状动脉慢血流（SCF）现象的危险因素。方法选取自2010年9月至2015年6月在第四军医大学西京医院心血管内科行冠脉造影的45 230例患者,其中,560例SCF患者作为观察组;同时期325例冠状动脉血流正常患者为对照组。研究两组患者临床资料和生化检查结果的显著性水平,并进行Logistic多元回归分析。结果 SCF现象占冠脉造影检查患者的0.93%,两组患者射血分数、高血压病、糖尿病、总胆固醇、甘油三酯、低密度脂蛋白、丙氨酸转氨酶、谷草转氨酶、血糖、C反应蛋白、胱抑素C、血钾、脑钠肽前体、肌钙蛋白、肌酸激酶同工酶、白细胞和血小板计数比较,差异无统计学意义（P〉0.05）。观察组男性患者例数、年龄、吸烟者例数、烟龄、吸烟指数、肌酐、尿素、血红蛋白浓度均高于对照组,差异有统计学意义（P〈0.05）。两组患者的心率、高密度脂蛋白、血清载脂蛋白a1、血清载脂蛋白B比较,差异明显,有统计学意义（P〈0.05）。Logistic多元回归分析结果显示,性别（OR=0.511,95%可信区间0.374-0.698,P〈0.05）,年龄（OR=1.044,95%可信区间1.031-1.056,P〈0.05）,烟龄（OR=1.028,95%可信区间1.017-1.038,P〈0.05）,心率（OR=0.987,95%可信区间0.978-0.997,P〈0.05）,高密度脂蛋白（OR=0.548,95%可信区间0.404-0.742,P〈0.05）,尿酸（OR=1.001,95%可信区间1.000-1.002,P〈0.05）为SCF的危险因素。结论性别、年龄、烟龄、心率、高密度脂蛋白降低、尿酸增多为本地区SCF的独立危险因素。
Objective To investigate the risk factors of slow coronary flow（ SCF） phenomenon. Methods A total of 45 230 patients received routine coronary angiography from September 2010 to June 2015,560 cases with SCF and 325 cases with normal coronary flow conformed by the standards of diagnosis and selection,were appointed to the observation group and the control group,respectively. Results The ratio of SCF in coronary angiography was 0. 93%. Two groups of patients with left entricular ejection fraction,hypertension,diabetes,total cholesterol,triglyceride,low density lipoprotein cholesterol（ LDL-C）,alanine aminotransferase,aspertate aminotransferase,blood glucose,c-reactive protein,potassium,suppression of brain natriuretic peptide precursor,troponin,creatine kinase isoenzyme,white blood cell and platelet counts,there was no statistically significant difference（ P〉0. 05）. The numbers of male patients,age,smokers,the proportion of smoking history,smoking index,creatinine,urea,hemoglobin concentration were higher than those in the control group,the differences were statistically significant（ P〈0. 05）. The heart rate,HDL,Apoa1 and Apo B were statistically significant between the two groups,（ P〈0. 05）. By multivariate logistic regression analysis,gender（ OR = 0. 511,95% CI 0. 374-0. 698,P = 0）,age（ OR = 1. 044,95% CI 1. 031-1. 056,P〈0. 05）,length as a smoker（ OR = 1. 028,95% CI 1. 017-1. 038,P〈0. 05）,heart rate（ OR = 0. 987,95% CI 0. 978-0. 997,P〈0. 05）,high density lipoprotein（ OR = 0. 548,95% CI 0. 404-0. 742,P〈0. 05） and uric acid（ OR = 1. 001,95% CI 1. 0-1. 002,P〈0. 05） were risk factors of SCF. Conclusion Gender,age,smoking history,increased heart rate,low high-density lipoprotein cholesterol（ HDL-C） and uric acid are the independent risk factors of SCF in this region.
出处
《临床军医杂志》
CAS
2016年第9期934-937,共4页
Clinical Journal of Medical Officers
