摘要
目的分析非糖尿病人群中腰臀比与慢性肾脏病的相关性,比较其在男性和女性中的差异。方法选择2012年6月~10月我国南方社区居民进行横断面筛查（n=2142）,排除糖尿病人群。将参与者分为男性组和女性组,并以腰臀比四分位数将男女各分为4组。采用Logistic回归模型分析在非糖尿病人群中腰臀比与慢性肾脏病的相关性,并比较其在男性和女性中的差异。结果在女性非校正模型中,腰臀比与慢性肾脏病显著相关（OR 7.29,95%CI 3.56 to 16.32,P〈0.001）。在校正潜在混杂因素如年龄、高血压史、冠心病史、吸烟饮酒史、收缩压、舒张压、甘油三酯、高密度脂蛋白后,二者仍相关（OR 6.13,95%CI 2.56 to 15.20,P=0.003）。在男性非校正模型中,腰臀比四分位数最高与最低组慢性肾脏病与腰臀比的OR值为2.44（95%CI,0.98 to 4.97,P=0.103）。结论在非糖尿病人群中,女性腰臀比是慢性肾脏病独立危险因素,在男性中无相关性。
Objective To explore the relationship between waist-to-hip ratio （WHR） and chronic kidney disease （CKD） in non-diabetic subjects and compare the difference between male and female subjects. Methods We performed a cross-sectional survey among 2142 community-based southern Chinese participants without diabetes from June to October 2012. We divided all the participants into 4 groups according to the gender-specific quartiles of WHR. Logistic regression models were used to explore the associations of WHR with CKD in these subjects. Results In the unadjusted model, WHR was significantly associated with CKD in women （OR=7.29, 95%CI：3.56-16.32, P〈0.001）, and the association was still significant （OR=6.13, 95%CI：2.56-15.20, P=0.003 ） after adjustment for the potential confounders （including age, history of hypertension, coronary heart disease, current smoker, physical inactivity, education level, systolic blood pressure, diastolic blood pressure, serum triglyceride, serum high density lipoprotein, blood glucose, and BMI）. The odds ratio （OR） for having CKD in the highest versus lowest quartile of WHR levels was 2.44 （95%CI：0.98-4.97, P=0.103） in men in the unadjusted model. Conclusion WHR levels are associated with CKD in non-diabetic women but not in non-diabetic male subjects.
作者
周琴
李永强
祝爽爽
刘新宇
邵小飞
李宾
王晓红
张瑛
王红蕾
黎嘉敏
邓康平
刘琴
邹和群
ZHOU Qin LI Yongqiang ZHU Shuangshuang LIU Xinyu SHAO Xiaofei LI Bin WANG Xiaohong ZHANG Ying WANGHonglei LI Jiamin DENG Kangping LIU Qin ZOU Hequn(Department of Nephrology, Institute of Nephrology and Urology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China)
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2016年第9期1221-1225,共5页
Journal of Southern Medical University
基金
国家自然科学基金(81270840)~~
关键词
腰臀比
慢性肾脏病
性别
非糖尿病人群
waist-to-hip ratio
chronic kidney disease
gender
non-diabetic subjects
