摘要
目的探讨甘露聚糖肽注射液配合化疗对晚期鼻腔NK/T细胞淋巴瘤疗效的影响。方法将30例晚期鼻腔NK/T细胞淋巴瘤患者分为治疗组和对照组各15例,均使用DEVIC方案化疗,治疗组同时予以甘露聚糖肽注射液输注,对照组予以胸腺肽注射液输注,观察2组疗效。结果治疗组总有效率66.7%(10/15),对照组总有效率40.0%(6/15)。治疗后治疗组白细胞、中性粒细胞下降幅度均明显低于对照组,差异有统计学意义(P<0.05);治疗组Karnofsky评分较治疗前提高,对照组变化不大,2组治疗后比较差异有统计学意义(P<0.05)。结论对于鼻腔NK/T细胞淋巴瘤,甘露聚糖肽注射配合化疗有利于提高近期疗效、改善患者生活质量和降低毒副反应。
Objective To investigate the effect of chemotherapy combined with Mannatide injection on the treatment of late nasal NK/T cell lymphoma. Methods 30 cases of advanced nasal NK/T cell lymphoma were divided into treatment group and control group with 15 eases respectively, using DEVIC chemotherapy, and the treatment group used Mannatide at the same time, while the control group received Thymopeptide Enteric. Then, the curative effects of two groups were observed. Results The total efficiency of treatment group was 66.7% （ 10/15 ） while 40% （ 6/15 ） in the control group. The decrease of white blood cells and neutrophils in treatment group were significantly lower than the control group （P〈0.05）. Kamofsky score in treatment group was increased compared with before treatment, while Karnofsky score in treatment group did not change （P〈0.05）. Conclusion Nasal NK/T cell lymphoma chemotherapy combined with Mannatide injection could improve the curative effect, enhance the quality of life as well as reduce the adverse reaction, which worthy of further clinical study.
出处
《基层医学论坛》
2016年第28期3914-3916,共3页
The Medical Forum
