摘要
目的比较不同药物对消化性溃疡出血患者止血效果、不良反应及复发率的影响.方法随机选取衢州市人民医院2014-05/2016-05收治的80例消化性溃疡出血患者,依据治疗方法将这些患者分为泮托拉唑组(n=40)和奥美拉唑组(n=40)两组,对两组患者的黑便次数、呕血次数、出血量、出血停止时间、临床疗效、不良反应发生情况及复发情况进行统计分析.结果治疗后1、3 d泮托拉唑组患者的出血量均显著少于奥美拉唑组(P<0.05),出血停止时间显著短于奥美拉唑组(P<0.05);两组患者治疗的总有效率97.5%(39/40)、95.0%(38/40),不良反应发生率及复发率之间的差异均不显著(P>0.05).结论泮托拉唑对消化性溃疡出血患者止血效果较奥美拉唑好,更能早期有效减少患者的出血量,缩短患者的出血停止时间,但二者对患者不良反应发生率及复发率的影响之间的差异均不显著.
AIM To compare pantoprazole with omeprazole in patients with peptic ulcer bleeding with regard to hemostasis effect,adverse reactions and relapse.METHODS Eighty patients with peptic ulcer bleeding who were treated at our hospital from May 2014 to May 2016 were randomly selected and divided into either a pantoprazole group（n=40） or an omeprazole group（n=40）.The number of black stools,vomiting times,amount of bleeding,time to hemostasis,clinical efficacy,adverse events and recurrence were compared between the two groups.RESULTS The bleeding at 1 d and 3 d after treatment was significantly less（P 〈0.05）,and the time to hemostasis was significantly shorter in the pantoprazole group than in the omeprazole group（P 〈0.05）.The total effective rate[97.5%（39/40） us 95.0%（38/40）],the incidence of adverse reactions[25.0%（10/40） us 22.5%（9/40）]and recurrence rate[0 us 2.5%（1/40）]did not differ significantly between the two groups（P 〉0.05）.CONCLUSION The hemostasis effect of pantoprazole is better than that of omeprazole in patients with peptic ulcer bleeding.Pantoprazole is more effective in reducing the amount of bleeding and shortening the time to hemostasis,although there is no significant difference in the incidence of adverse reactions and recurrence rate between the two groups.
出处
《世界华人消化杂志》
CAS
2016年第28期4008-4012,共5页
World Chinese Journal of Digestology
