摘要
目的观察穴位敷贴联合塞来西布治疗膝骨关节炎(KOA)的临床疗效。方法将80例KOA患者随机分为两组。治疗组采取穴位敷贴联合塞来昔布进行治疗,对照组患者只采用塞来昔布进行治疗。结果治疗组患者的膝关节功能(Lysholm)评分和疗效均优于对照组(P<0.05),治疗后的临床症状情况优于对照组(P<0.05),白细胞介素-1α(IL-1α)、肿瘤坏死因子α(TNF-α)水平和膝关节软骨中的基质金属蛋白酶-1(MMP-1)水平低于对照组(均P<0.05)。结论穴位敷贴联合塞来西布在膝骨关节炎患者的治疗中具有良好的效果,值得在临床中大力的推广和运用。
Objective To observe the acupoint application combined with Celecoxib in treatment of knee osteoarthritis（ KOA） patients.Methods 80 cases of KOA patients were randomly divided into observation group and control group,observation group received point application combined with Celecoxib only,control group recevied Celecoxib. After 2 months of treatment,evaluate the use of knee function（ Lysholm） scale evaluation of patients with the therapeutic effect; comparative analysis of clinical symptoms in both groups of before and after treatment; analysis of the knee effusions interleukin- 1α（ interleukin- 1α,IL- 1α）,tumor necrosis factor- α（ tumor necrosis Factor-α,TNF- α） levels and knee cartilage matrix metalloproteinase- 1（ matrix metalloproteinase- 1,MMP- 1） levels of both groups. Results Lysholm score and efficacy in observation group were better than those of control group,the clinical symptoms of the situation after treatment was better than control group,IL- α,TNF- α levels and knee cartilage MMP- 1 levels were lower than those of control group,the above differences were statistically significant（ P〈0. 05）. Conclusions Acupoint application combined with Celecoxib has good effect in treatment of KOA,it is worthy of wide promotion and application in clinical.
作者
李小宏
陈大为
LI Xiaohong CHEN Dawei(Department of rehabilitation medicine, No. 1 Affiliated Hospital of Chongqing Medical University, Chongqing 400016)
出处
《湖北中医药大学学报》
2016年第5期32-34,共3页
Journal of Hubei University of Chinese Medicine
基金
重庆市卫计委中医药项目(项目编号:2Y201402110)
关键词
膝骨关节炎
中西医结合疗法
穴位敷贴
塞来昔布
osteoarthritis
integrated Chinese-western therapy
acupoint application
Celecoxib
