摘要
目的比较低剂量索他洛尔与普罗帕酮治疗心律不齐患者的临床疗效及对QT离散度(QTd)的改善作用。方法选取2011年9月至2013年2月在我院治疗的心律不齐患者104例为研究对象,采用随机数字表法随机分为观察组与对照组,每组52例。观察组患者给予低剂量索他洛尔注射治疗,对照组患者给予普罗帕酮注射治疗,比较两组患者的治疗总有效率、QTd变化以及不良反应发生情况。结果观察组患者治疗总有效率为88.5%,对照组患者为82.7%,两组患者的临床治疗效果比较差异无统计学意义(P>0.05)。治疗后观察组患者最大QT、最小QT增大,QTd变小,与治疗前比较差异有统计学意义(P<0.05);对照组最大QT、最小QT与QTd治疗前后变化不明显(P>0.05);治疗后两组最大QT、最小QT及QTd比较差异有统计学意义(P<0.01)。两组患者治疗过程头晕头疼、恶心腹泻、呼吸困难、低血压、心力衰竭发生情况比较差异均无统计学意义(P>0.05)。结论低剂量索他洛尔与普罗帕酮治疗心律不齐患者临床效果相当,不良反应发生情况也无明显差别,但低剂量索他洛尔治疗对心律不齐患者QTd的改善作用更加显著。
Objective To compare the effect of low-dose sotalol and propafenone in the treatment of patients with arrhythmia and its impacts on QTd. Methods A total of 104 patients with arrhythmia admitted to our hospital from September 2011 to February2013 were selected and randomly divided into observation group and control group,with 52 cases in each group. The observation group was treated with low-dose sotalol while the control group received propafenone. The total effective rate,adverse effects and the changes of QTd were compared between the two groups. Results The total effective rate in the observation group was 88. 4%,and the control group was 82. 6%,there was no significant difference in total effective rate between two groups（P 〉 0. 05）. After treatment,maximum QT,minimum QT in the observation group were significantly longer than those before treatment,and the QTd was shorter than that before treatment（P 〈 0. 05）; maximum QT,minimum QT and QTd showed no improvemat after treatment in contrast with those before treatment in the control group（P 〉 0. 05）; the maximum QT,minimum QT in the observation group were significantly longer than those in the control group,and the QTd in the observation group was significantly shorter than that in the control group（P 〈 0. 05）. There was no significant difference in dizziness,headache,nausea,diarrhea,dyspnea,low blood pressure,heart failure between two groups（P 〉 0. 05）. Conclusions The effects of low-dose sotalol and propafenone in the treatment of patients with arrhythmia is similar,and there is no significant difference in the adverse reactions between the two,however,low-dose sotalol seems to be more effective than propafenone in QTd.
出处
《内科》
2016年第5期691-693,共3页
Internal Medicine
基金
广东省肇庆市科技创新计划项目(2014E211)
