摘要
瘙痒是指一种不愉快的、并即刻引起搔抓欲望的感觉,最常见于皮肤病,也可能是潜在的系统性疾病的皮肤表现。皮肤T细胞淋巴瘤(cutaneous T-cell lymphomas,CTCL)是一种可引起瘙痒的威胁生命的皮肤肿瘤。瘙痒可以继发于CTCL,也可以是CTCL的原发表现。瘙痒通常在CTCL疾病进展期或某些亚型中,症状较为严重,如亲毛囊性CTCL、Sézary综合征(Sézary syndrome,SS)以及红皮病型蕈样肉芽肿(Mycosis fungoides,MF),一般抗瘙痒治疗难以抑制。目前,关于CTCL瘙痒机制的研究处于起始阶段,研究发现多种介质与其相关,如白介素31、P物质、蛋白酶、胃泌素释放肽和神经生长因子等,且其治疗也主要依赖治疗原发病,针对性的靶向治疗很少,控制瘙痒多依赖于经验用药。本文对CTCL相关性瘙痒研究进展进行综述并做文献复习。
Pruritus is an unpleasant sensation provoking the desire to scratch. It mostly be seen in skin disorders, and might be a symptom of underlying systemic disease. Cutaneous T-cell lymphoma（CTCL）is a life-threatening cause of pruritus. Itch can be associated, or primary symptom of CTCL. If pruritus present in CTCL, it is often worse at the later stage of the disease and in certain variants such as folliculotropic Mycosis fungoides（MF）, Sézary syndrome（SS）and erythrodermic MF, and it could not be relieved by conventional treatment. So far, the research surrounding the mechanism of pruritus in CTCL is just beginning, and researchers find out several mediators associated with itch in this disease, such as interleukin 31, P substance, proteinases, gastrin-releasing peptide and nerve growth factors. Targeted itch therapy is rare, and the treatment is very difficult and mostly experience-directed. Here we summarize and review the published research on the mechanism and treatment of pruritus in CTCL.
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2016年第11期1178-1181,共4页
The Chinese Journal of Dermatovenereology
基金
国家自然科学基金面上项目(编号:81372915)
首都临床特色应用研究(编号:Z131107002213028)
北京大学第三医院院临床重点项目(编号:BYSY201209)
关键词
淋巴瘤
T细胞
皮肤
瘙痒
Lymphoma
T-cell
Cutaneous
Pruritus
