摘要
目的分析G蛋白偶联受体30(GPR30)在宫颈癌组织中表达的临床意义。方法选取2012年9月—2015年6月收集的68例宫颈病变组织标本,其中宫颈癌组38例,宫颈上皮内瘤样病变(CIN)组30例,另选择来院行妇科检查的20例正常宫颈组织作为对照组,观察3组宫颈组织CPR30的表达水平,并分析其与宫颈癌临床病理参数的关系。结果宫颈癌组和CIN组宫颈组织GRP30表达阳性率和GRP30 mRNA相对表达量均高于对照组,且宫颈癌组高于CIN组(P<0.05);不同分化程度、不同临床分期宫颈癌组织GPR30阳性率比较差异有统计学意义(P<0.05)。结论 GPR30参与宫颈癌的发生及进展,且与肿瘤分化程度、临床分期密切相关。
Objective To analyze expression of G-protein-coupled receptor 30（ GPR30） in cervical cancer tissues and its clinical significance. Methods A total of 68 specimens of cervical tissues during September 2012 and June2015 were collected,and were divided into cervical cancer group（ n = 38） and cervical intraepithelial neoplasia group（ CIN group,n = 30）,and then normal cervical tissues from 20 controls with gynecological examination at the same time were collected as control group. CPR30 expression levels in three groups were observed,and its correlations with clinicopathological parameters were analyzed. Results Positive rates of GRP30 expression and relative expression quantity of GRP30 mRNA in cervical cancer and CIN groups were higher than those in control group,and the values in cervical cancer group were higher than those in CIN group（ P〈0. 05）. There were significant differences in positive rates of GPR30 between cervical cancer tissues of different differentiation degrees and clinical stages（ P〈0. 05）. Conclusion GPR30 is involved in pathogenesy and development of cervical cancer,and it closely relates to differentiation and clinical stage of tumor.
出处
《解放军医药杂志》
CAS
2016年第10期50-53,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词
宫颈肿瘤
宫颈上皮内瘤样病变
受体
雌激素
受体
G-蛋白偶联
Cervix neoplasms
Cervical intraepithelial neoplasia
Receptor
estrogen
Receptor
G-protein coupled
