摘要
目的探讨胎盘多肽注射液联合化疗治疗下咽癌的效果。方法选择2010年8月—2012年8月收治的下咽癌37例,根据有无使用胎盘多肽注射液分为观察组20例和对照组17例。对照组给予单纯化疗治疗,观察组在对照组基础上给予胎盘多肽注射液,均治疗3个周期。评估两组临床疗效及化疗毒副反应,检测T淋巴细胞和自然杀伤(NK)细胞、鳞状细胞癌相关性抗原(SCCAg)、癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、角化素蛋白片段19(CYFRA21-1),评估患者功能状态及生活质量;记录1、3年存活率。结果两组总有效率及1、3年生存率比较差异无统计学意义(P>0.05);观察组治疗后CD4+、CD4+/CD8+、NK细胞较治疗前和对照组升高,对照组治疗后较治疗前下降(P<0.05);两组治疗后SCCAg、CEA、CA19-9、CYFRA21-1均较治疗前下降,且观察组低于对照组(P<0.05);两组治疗后功能状态评分高于治疗前,生活质量调查问卷评分低于治疗前,且观察组改善情况优于对照组(P<0.05)。观察组消化道反应、白细胞下降、血小板下降发生率低于对照组(P<0.05)。结论胎盘多肽注射液联合化疗治疗下咽癌可改善机体免疫功能,降低血清肿瘤标志物水平,提高化疗耐受性。
Objective To investigate efficacy of Placenta Polypeptide injection combined with chemotherapy in treatment of hypopharyngeal cancer. Methods A total of 37 patients with hypopharyngeal cancer admitted between August 2010 and August 2012 were divided into observation group（ n = 20） and control group（ n = 17） according to whether use Placenta Polypeptide injection or not. Control group was treated with simple chemotherapy,while observation group was added with Placenta Polypeptide injection on the basis of control group. All patients were treated for 3 cycles. In two groups,curative effects and side effects of chemotherapy were evaluated; levels of T lymphocytes and natural killer（ NK）cells,squamous cell carcinoma associated antigen（ SCCAg）,carcinoembryonic antigen（ CEA）,carbohydrate antigen19-9（ CA19-9） and cytokeratin fragment 19（ CYFRA21-1） were detected; functional status and quality of life were evaluated; 1-year and 3-year survival rates were recorded. Results There were no significant differences in total effective rate,1-year and 3-year survival rates between two groups（ P〈0. 05）. After treatment,levels of CD4 ＋,CD4 ＋ / CD8 ＋and NK cells in observation group were higher than those before treatment in same group and those in control group,while the levels in control group were lower than those before treatment（ P〉0. 05）. After treatment,levels of SCCAg,CEA,CA19-9 and CYFRA21-1 were lower than those before treatment in both groups,and the levels in observation group were lower than those in control group（ P〈0. 05）; in two groups,karnofsky（ KPS） scores were higher,while scores of quality of life questionnaire were lower than those before treatment,and improvement in observation group was better than that in control group（ P〈0. 05）. Incidence rates of digestive tract reactions,leukopenia and platelet descend in observation group were lower than those in control group（ P〈0. 05）. Conclusion Placenta Polypeptide injection combined with chemotherapy in treatment of hypopharyngeal cancer can improve immune function,reduce levels of serum tumor markers and improve tolerance to chemotherapy of patients.
出处
《解放军医药杂志》
CAS
2016年第10期54-57,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词
下咽肿瘤
胎盘提取物
肽类
化疗
治疗结果
Hypopharyngeal neoplasms
Placental extracts
Peptides
Chemotherapy
Treatment outcome
