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大黄素抗炎作用及相关机制研究进展 被引量:36

Advances in research on antiinflamatory activity and related mechanisms of emodin
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摘要 大黄素为蒽醌类衍生物,具有利尿、舒张血管、抗菌、抗病毒、抗炎和抗癌等药理活性。关于大黄素抗炎作用的研究报道日益增多,体内和体外试验已证明大黄素对多种炎症具有调节作用。其作用机制可能为大黄素与许多炎症过程中的重要分子和炎性细胞(NF-κB、PPAR、inflammasome、SDF-1和巨噬细胞等)相互作用,通过多种途径调节炎症反应,避免过度炎症对组织的损伤。本文对近5年来大黄素抑制多种炎症的活性和相关机制进行综述,为大黄素抗炎机制的阐明及相关药物的研发提供参考。 Objective Emodin is a natural occurring anthraquinone derivative isolated from roots,which has diuretic,vasorelaxant,anti-bacterial,anti-viral,anti-inflammatory,and anti-cancer effects in previous researches. More and more researches on the antiinflamatory activities of emodin have been reported recently. The anti-inflammatory effects of emodin have been exhibited in various in vitro as well as in vivo models of inflammation. The mechanisms may be that emodin is a pleiotropic molecule capable of interacting with several major molecular targets and cell including N F-κB,PPAR,inflammasome,SDF-1 and macrophage which are involved in inflammation. This reviewsummarizes reported anti-inflammatory activities and mechanisms of emodin so as to provide references for the further elucidation of emodin antiinflamatory mechanisms and the development of the related drugs.
出处 《济宁医学院学报》 2016年第5期348-352,共5页 Journal of Jining Medical University
基金 2008年济宁医学院青年基金(077801) 2015年山东省高等学校优季青年教师国内访问学者奖励项目
关键词 大黄素 抗炎作用 机制 Emodin Antiinflamatory activity Mechanism
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