摘要
目的检测慢性肾脏疾病(CKD)患者常见肿瘤标志物的水平,探讨常见肿瘤标志物与慢性肾脏疾病不同分期的关系。方法随机选取2014年6月—2015年12月武汉大学人民医院肾病内科住院患者200例,分别检测血清常见肿瘤标志物人类附睾蛋白4(HE4)、糖类抗原72-4(CA72-4)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、鳞状细胞癌抗原(SCC)、α-甲胎蛋白(AFP)、糖类抗原125(CA125)、糖类抗原19-9(CA19-9)和癌胚抗原(CEA)水平,其中HE4,CA72-4,CYFRA21-1和NSE检测应用罗氏全自动化学发光免疫分析仪E601,SCC检测应用雅培全自动发光免疫分析仪I2000,AFP、CA125、CA19-9和CEA检测采用西门子全自动发光免疫分析仪Advia Centaur XP。结果肿瘤标志物在CKD不同分期组和健康组间进行比较发现,HE4、CA72-4、SCC、CYFRA21-1、CA125、CA19-9和CEA在CKD不同分期组间的差异有统计学意义(F_(HE4)=96.06,F_(CA72-4)=2.59,F_(SCC)=14.88,F_(CYFRA21-1)=5.10,F_(CA125)=8.94,F_(CA19-9)=2.68,F_(CEA)=2.88,均P<0.05),而NSE和AFP在CKD不同分期间差异无统计学意义(F_(NSE)=0.686,F_(AFP)=1.39,均P>0.05)。对CKD5期患者透析组和未透析组间肿瘤标记物进行比较,结果发现仅HE4(t=3.09,P<0.05)和CEA(t=2.65,P<0.05)在两组间比较,差异有统计学意义;而CA72-4,SCC,CYFRA21-1,NSE,AFP,CA125和CA19-9在两组间比较,差异无统计学意义(|t|<1.2,均P>0.05)。结论 CKD分期和血液透析影响肿瘤标志物的浓度,可作为临床CKD诊断、减少误诊的参考指标。
[Objective] To detect the levels of common tumor markers in patients with chronic kidney disease（CKD）,explore the relationship between the common tumor markers and the different stages of CKD. [Methods] 181 CKD inpatients were randomly selected from Renal Medicine Department of Renmin Hospital of Wuhan University fro June 2014 to December 2015,to detect levels of common tumor markers,including HE4,CA72-4,CYFRA21-1,NSE,SCC,AFP,CA125,CA19-9 and CEA.HE4,CA72-4,CYFRA21-1 and NSE were detected by automatic analyzer E601,SCC was detected by automatic analyzer I2000,and AFP,CA125,CA19-9 and CEA were detected by automatic analyzer Advia Centaur XP. [Results]The differences in levels of HE4,CA72-4,SCC,CYFRA21-1,CA125,CA19-9 and CEA were statistically significant among different stages of CKD（FHE4=96.06,FCA72-4=2.59,FSCC=14.88,FCYFRA21-1=5.10,FCA125=8.94,FCA19-9=2.68,FCEA=2.88,P〈 0.05）,and there were no statistically significant differences in levels of NSE and AFP among different stages of CKD（FNSE=0.686,FAFP=1.39,〉P0.05）.Among patients in stage 5 of CKD,the differences in levels of HE4（t =3.09,P〈 0.05） and CEA（t =2.65,P 〈0.05） were statistically significant between hemodialysis group and non-hemodialysis group, and there were no statistically significant differences in levels of CA72-4,SCC,CYFRA21-1,NSE,AFP,CA125 and CA19-9 between two group（｜t｜〈1.2,P〉 0.05）.[Conclusion]The levels of tumor markers are affected by stages of CKD and hemodialysis,which can be used as reference index of CKD diagnosis to reduce the misdiagnosis.
出处
《职业与健康》
CAS
2016年第18期2501-2504,2507,共5页
Occupation and Health
关键词
肿瘤标志物
慢性肾脏疾病
血液透析
分期
Tumor markers
Chronic renal disease（CKD）
Hemodialysis
Staging
