摘要
目的探讨不同剂量的泮托拉唑治疗急性非静脉曲张性上消化道出血(ANVUGIB)的临床效果。方法将我院收治的80例ANVUGIB患者随机分为大剂量组和常规剂量组,各40例,大剂量组给予大剂量泮托拉唑进行治疗,常规剂量组给予常规剂量的泮托拉唑进行治疗,比较两组患者的临床效果。结果两组患者治疗的总有效率、不良反应发生率差异无统计学意义(P>0.05);大剂量组平均止血天数、平均输血量、再出血率少于常规剂量组,差异均有统计学意义(P<0.05)。结论大剂量泮托拉唑治疗ANVUGIB能够明显减少止血时间和输血量,降低再出血率;常规剂量也可有效控制ANVUGIB病情,应根据患者实际情况加以选择。
Objective To explore the clinical effect of different dose of pantoprazole in the treatment of ANVUGIB. Methods Eighty cases of patients with ANVUGIB were randomly divided into high dose group and the conventional dose group, with 40 cases in each group. The high dose group was received high dose of pantoprazole, while the conventional group was given conventional dose. The clinical effect was compared between the two groups. Results There was no statistical significance in the total effective rate and adverse reactions rate （P 〉0.05）. The average bleeding days, average transfused blood, re-bleeding rate of the high dose group were lower than conventional group, the differences were statistically significant （P〈0.05）. Conclusion High dose of pantoprazole can significantly decrease the haemostasis time, transfusions and re-bleeding in treatment of ANVUGIB; the conventional dose can also control the condition of ANVUGIB; the actual treatment should be selected according to the situation of the patient.
出处
《临床医学研究与实践》
2016年第22期86-87,共2页
Clinical Research and Practice
