摘要
目的探讨血浆脂蛋白相关磷脂酶A2(Lp-PLA2)在缺血性脑血管病中的临床意义。方法检测87例缺血性脑血管病患者(A组)和50例健康体检者(B组)的血浆Lp-PLA2、TC、HDL-C、LDL-C、脂蛋白a(LPa)和FBG水平。结果与B组相比,A组的血浆Lp-PLA2[(247.66±105.08)ng/ml vs.(103.16±20.90)ng/ml]、TC[(5.09±1.18)mmol/L vs.(4.43±0.59)mmol/L]、LDL-C[(3.72±0.88)mmol/L vs.(3.12±0.82)mmol/L]、LPa[(282.59±234.00)mg/L vs.(136.56±92.25)mg/L]和FBG[(6.04±1.51)mmol/L vs.(5.55±0.57)mmol/L]水平均较高(P<0.01),HDL-C[(1.08±0.29)mmol/L vs.(1.43±0.28)mmol/L]水平较低(P<0.01)。Lp-PLA2诊断缺血性脑血管病的敏感度、特异度、准确性、阳性预测值和阴性预测值分别为60.92%、76.00%、66.42%、81.54%和52.78%;血浆Lp-PLA2水平与缺血性脑血管病严重程度密切相关(P<0.01)。结论血浆Lp-PLA2是预测缺血性脑血管病风险的一个生物学标志物。
Objective To investigate the clinical significance of lipoprotein‐associated phospholipase A2 （Lp‐PLA2 ） in ischemic cerebrovascular diseases .Methods Plasma levels of Lp‐PLA2 ,TC ,HDL‐C ,LDL‐C ,LPa and FBG were detected in 87 patients （group A ） with ischemic cerebrovascular diseases and 50 healthy subjects（group B） .Results Compared with group B ,group A showed higher levels of Lp‐PLA2[（247.66 ± 105.08）ng/ml vs .（103.16 ± 20.90）ng/ml] ,TC[（5.09 ±1.18）mmol/L vs.（4.43±0.59）mmol/L],LDL‐C[（3.72±0.88）mmol/L vs.（3.12±0.82） mmol/L],LPa[（282.59 ± 234.00） mg/L vs .（136.56 ± 92.25） mg/L] and FBG[（6.04 ± 1.51） mmol/L vs .（5.55 ± 0.57）mmol/L]（P〈0 .01） and lower level of HDL‐C[（1.08 ± 0.29）mmol/L vs . （1.43 ± 0.28） mmol/L]（P〈0 .01） .The sensitivity ,specificity ,accuracy ,positive predictive value and negative predictive value of Lp‐PLA2 in the diagnosis of ischemic cerebrovascular diseases were 60.92% ,76.00% ,66.42% ,81.54% and 52.78% .The level of Lp‐PLA2 was positively correlated to the severity of ischemic cerebrovascular diseases （ P〈0 .01 ） .Conclusion The Lp‐PLA2 possibly becomes a biological indicator ,which predicts the risk of ischemic cerebrovascular diseases .
作者
宋为娟
张伟
任真
杨瑞霞
SONG Weijuan ZHANG Wei REN Zhen et al .(Department of Laboratory Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, CHINA)
出处
《江苏医药》
CAS
2016年第20期2237-2239,共3页
Jiangsu Medical Journal
