摘要
目的：了解中国厦门地区献血者细小病毒B19感染情况。方法：对中国厦门地区部分献血者标本进行细小病毒B19核酸检测和抗体检测,对核酸检测阳性标本进行序列测定和基因型分析。结果：在总共10 452人份献血者标本中检出6例B19核酸阳性,阳性率0.06%,阳性标本的DNA定量结果为3.59×102-1.07×104IU/ml;6例核酸阳性标本测序分析结果均为基因I型。B19-Ig M抗体阳性率为4.64%（50/1078）,B19-Ig G阳性率16.79%（181/1078）;B19-Ig G阳性率随年龄增加而升高（χ2=7.964,P〈0.05）,与性别差异无关。结论：中国厦门地区献血者细小病毒的总体感染率较其他地区偏低,但也存在一定比例的病毒血症,在今后的输血保障工作中应引起重视。
Objective：To estimate the prevalence of parvovirus B19 infection in Chinese Xiamen area blood donors.Methods：Blood samples from blood donors were tested for detection of parvovirus B19 DNA and antibody.The direct sequencing and genetype analysis of B19 DNA positive samples were performed.Results：Six out of 10452 samples were B19 DNA positive.The viral loads of the 6 samples were between 3.59×102-1.07×104 IU/ml;the positive rate of B19-IgM was 4.64%（50/1 078） and B19-IgG was 16.79%（181/1078）.The positive rate of B19-IgG increased with ages,and was not related with the sex.Conclusion：The overall prevalence of parvovirus B19 infection in blood donors is lower in Chinese Xiamen area than that in other areas,however,there is still a certain percentage of viremia in donors and the attention should be paid to blood safety in the future work.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2016年第5期1572-1576,共5页
Journal of Experimental Hematology
基金
福建省自然科学基金面上项目(2012D049)
厦门市输血医学重点专科项目(2012-2014)
