摘要
目的:采用免疫组化技术探讨不同程度宫颈病变组织中P16、Ki-67的表达。方法:收集770例宫颈上皮内瘤变病理标本,进行常规病理诊断和免疫组化检测,观察P16、Ki-67在宫颈标本中的表达。结果:随着宫颈疾病的加重,P16呈逐渐弥漫阳性表达,并且阳性表达率逐渐增加,同时Ki-67指数也同时升高。结论:宫颈病理标本进行P16联合Ki-67检测可以提高诊断准确率,减少误诊漏诊。
Objective：To investigative the expression of P16 and Ki-67 in different degree of cervical lesion using immunohistochemistry.Method：A total of 770 patients with cervial intraepithelial neoplasia were chose and received routine pathological diagnosis and immunohistochemical detection of P16 and Ki-67.Result：P16 was gradually filled with positive expression and positive expression rate increased with higher Ki-67 index following the deterioration of cervical diseases.Conclusion：Immunohistochemical detection of P16 and Ki-67 might improve diagnistic accuracy and decrease misdiagnosis.
出处
《中国医学创新》
CAS
2016年第29期48-51,共4页
Medical Innovation of China
基金
柳州市科学研究与技术开发计划项目(2014J030418)
关键词
宫颈上皮内瘤变
病理诊断
免疫组化
Cervical conization intraepithelial neoplasia
Pathological diagnosis
Immunohistochemistry
